A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.

A medical device for delivering a drug compound through a stratum corneum includes a support having an aperture, an array of microneedles extending outwardly from the support, a plurality of nanostructures associated with each microneedle, and a reservoir wherein the drug compound is retained. At least one microneedle contains a shaft extending from the support. The shaft includes a tip configured to penetrate the stratum corneum. The shaft defines a channel extending from the support to the tip. The channel is in at least partial alignment with the aperture. At least some of the microneedles of the array of microneedles each have a cross-sectional dimension of from about 1 micrometer to about 1 millimeter. At least some of the nanostructures have a cross-sectional dimension less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5.

Described herein are technologies, methods, and/or devices for treating skin (e.g., eliminating tissue volume, tightening skin, lifting skin, and/or reducing skin laxity) by selectively excising a plurality of microcores without thermal energy being imparted to surrounding (e.g., non-excised) tissue. The technologies, methods, and/or devices described herein satisfy an unmet need for rapid and safe treatment of skin, including, e.g., faster pretreatment preparation and post-treatment healing times compared to current surgical and thermal treatment methods.

A cell transplantation device is used to place a graft containing cells into a target region in a living body. The cell transplantation device includes a needle extending in one direction, and a filter unit made of a fibrous member. The needle has a flow channel defined therein and an opening at the tip of the needle. The filter unit is disposed at an intermediate position in the flow channel and configured to retain a graft between the filter unit and the opening when a liquid material containing the graft enters the flow channel through the opening.

Sheathed cutting device. An exemplary device for discreetly piercing a skin of a patient can comprise a body having a proximal end and a distal end, a cutting member attached to a plunger, the cutting member and the plunger positioned at least partially within the body, and a biasing member configured to bias the cutting member to an initial position whereby the cutting member is positioned fully within the body, wherein the plunger is slidable into the proximal end of the body, causing the cutting member to extend from the distal end of the body.

A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.

A device for repeated intradermal injections within an organic tissue. The device comprises a support defining an internal housing for receiving a vial containing an aqueous solution, a source of pressurized air in fluid communication with the vial, a tube defining a pressurized solution path, a hollow injection needle, an injection head, a driven element with a distal end connected to the injection head, an actuator connected to the driven element, and a valve in fluid communication with the pressurized solution path for controlling a flow of the pressurized solution into the tube from the vial up to the distal end of the hollow injection needle.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

The present invention provides a method for generating an immune response in a subject, comprising administering to the subject's skin an immunizing composition from a SARS-CoV-2 pathogen, wherein the composition is administered with a microneedle delivery device.

An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a water-soluble polymer, influenza vaccine, and meglumine or a salt thereof, and the influenza vaccine is administered into a body by dissolution of the needle portions.