An ultrasonic transducer assembly of an ultrasonic surgical instrument includes a piezoelectric stack, an ultrasonic horn secured to and extending distally from the piezoelectric stack and including a body and a nose extending distally from the body, an overmold seal formed about the body of the ultrasonic horn, and a casing disposed about the piezoelectric stack, the body of the ultrasonic horn, and the overmold seal. The casing defines a distal opening through which the nose of the ultrasonic horn extends. The overmold seal establishes a hermetic seal with the casing to define a hermetically sealed interior enclosing the piezoelectric stack and the body of the ultrasonic horn therein.

Methods and devices are disclosed that enable safe, rapid and relatively short and straight access to the cerebral arteries for the introduction of interventional devices to treat acute ischemic stroke. In addition, the disclosed methods and devices provide means to securely close the access site to the cerebral arteries to avoid the potentially devastating consequences of a transcervical hematoma.

A catheter that fits within a blood vessel wall includes electrodes aligned along a longitudinal axis of the catheter that produce unfocused shock waves that propagate radially toward the blood vessel wall for treatment.

In some examples, the disclosure describes a medical assembly that includes a stent including a primary electrode, where the stent is configured to expand from a collapsed configuration to an expanded configuration, a secondary electrode, and an energy source configured to deliver an electrical signal between the primary electrode and the secondary electrode through a fluid in contact with the primary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

An ultrasound catheter system and a method for operating an ultrasonic catheter at a treatment site within a patient's vasculature or tissue are disclosed. The ultrasound catheter system comprises a catheter having at least one ultrasonic element and a control system configured to generate power parameters that drive the at least one ultrasonic element to generate ultrasonic energy. The control system is configured to vary at least one of the power parameters and at least one physiological parameter by repeatedly cycling the power parameter and the physiological parameter through two set of values.

Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.

An ultrasonic intracranial sonothrombolysis pressure amplitude is pre-quantified by using an ultrasound-scanner control unit (110) having an increasing and/or decreasing mode and designed for: with respect to a current mode, interrogating a blockage site iteratively so as to progressively and respectively increase or decrease a pressure amplitude of ultrasound being emitted to the site at which bubbles (144) for oscillating that is caused by the emitted ultrasound are present; iteration to iteration, deriving, from echoes of the emitted ultrasound, a magnitude of an energy of a signal; and automatically identifying, for the quantifying, an iteration that, in comparison with a just-previous iteration, fails to increase the magnitude. The interrogating may span a region that contains or goes through: the obstruction; another part of the blood vessel; and bubble circulation within a neighboring vessel and a neighboring capillary (136). The deriving can be based on an ultraharmonic signal, with band-pass filtering being utilized to extract the ultraharmonic signal from returning signals differenced to remove stationary content.

The present invention relates to a device, system and a method for high pressure shockwave treatment of biological tissue having a large treatment zone and in particular to such a device, system and method in which a large biological treatment area in treated in a non-drug, non-surgical treatment protocol utilizing ballistic shockwave generating device.

A goniotomy surgical instrument (10) includes a hand grip portion (12) having an elongated configuration with proximal and distal ends. The instrument (10) includes a tip portion (14) extending from the distal end of the hand grip portion (12) and includes a shank (16) extending from the hand grip portion (12). The tip portion (14) includes a V-shaped distal end having first and second legs (18, 20). The first leg (18) extends at a first angle (α) from the shank (16) of the tip portion (14). The second leg (20) extends at a second angle (β) from the first leg (18). The shank (16) and the first and second legs (18, 20) are substantially coplanar.