A method of treating a calculi mass can include using an ultrasonic probe to produce acoustic energy and fragment the mass. The method can include varying the frequency at which fragmentation occurs to treat the mass with a resonant frequency. The ultrasonic probe can have a distal tip for contact with the mass, where the tip has a morphology for concentrating stress on the mass. The ultrasonic probe can have two or more ultrasonic horns to allow for higher voltage and power levels.

A wireless magnetic ultrasonic cavitation in-vivo therapeutic robotic device, including a micro-robot and an in-vitro control device; the in-vitro control device has an outer housing in which provided with electromagnetic coils and wireless power emitting coils; the micro-robot has a capsule shaped housing in which a super magnetic module is provided; a micro ultrasonic vibrator and a micro wireless power receiving coil electronically connected with each other are provided inside the housing; the wireless power emitting coils emit electromagnetic field to the micro wireless power receiving coil, which receives and then transforms the electromagnetic field to electrical current to supply power to the micro ultrasonic vibrator. The robotic device creates ultrasonic cavitation effect in the blood, causing rapid vibration of blood cells, which enhances cell regeneration power, burn blood lipids, clear blood clots and ensures good condition of blood vessels.

An ultrasonic horn, an ultrasonic transducer assembly including the same, and an ultrasonic surgical instrument including the same. The ultrasonic horn includes a body and a nose. The body defines a length and a maximum diameter of the ultrasonic horn. The body includes at least one depression arranged annularly thereabout that is configured to receive at least one protrusion for mounting the body within a support structure. The nose extends distally from the body. The body defines a proximal connector configured to enable the body to be secured to a piezoelectric stack and the nose defines a distal connector configured to enable the nose to be engaged with a waveguide for transmission of ultrasonic energy produced by the piezoelectric stack to the waveguide.

A method includes attaching one or more heat exchangers to one or more of a distal handle end and a proximal handle end of a lithotripter, the lithotripter including a handle, the handle having a handle distal end and a handle proximal end; a probe housed within the handle, the probe having a probe distal end and a probe proximal end; a passageway extending through the handle at least partially containing the probe; and a shielding insert contained within the passageway; wherein the probe, the passageway, and the shielding insert are contained within a central lumen of a driver resource; and performing a sterilization procedure on the surgical device; wherein the one or more heat exchangers collect and transfer heat at least through a full length of the handle, particularly to the lumen contained within the handle.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

A pressure wave device for the treatment of a human or animal body having a pneumatic drive for generating a pressure wave for coupling into the human or animal body, having at least one compressor for generating source gas and having a handpiece into which the source gas can be introduced and by means of which a pressure wave is generated, and having a pressure regulating device for adjusting a pressure wave generating pressure for generating the pressure wave, where the at least one compressor for generating source gas is adjustable in steps to at least two power levels, and the pressure regulating device regulates the pressure wave generating pressure (P.sub.D_i) by adjusting the source gas pressure (P.sub.s_i) at each power level, such that each power level is thereby preferably determined by a range of pressure wave generating pressure values and frequencies of the activation of the pressure waves, and the selection of a power level is preferably carried out using a table in which the respective ranges of pressure wave generating pressure values and frequencies are stored.

The present disclosure is directed to methods of treating subject patients (such as humans, animals, plants) suffering from a pathogenic disease such as COVID-19 in humans, via the administration of pressure changes in the patient sufficient to cause a pressure differential to be created between the inside and outside of the outer membrane or envelope of the pathogen thereby destroying or disabling the pathogen. In one embodiment, a hyperbaric chamber is used to administer pressure increases and/or pressure decreases to create such pressure differential. The hyperbaric chamber could comprise a single user or multi-user unit, a pressurized body suit, or the pressurizable fuselage of an aircraft. In another embodiment, patients are placed in an aircraft, and the cabin pressure, while on the ground, or in flight, is adjusted upwardly or downwardly to create such pressure differential. The pressure differential methods can also include the use of external gases to enter the patient's body and/or lungs to facilitate disruption of the pathogen outer membrane as well as application of variations in temperature and/or humidity. A mobile treatment unit is also disclosed. Also disclosed are methods of using ultrasonic cavitation or MRI (or other sonic or magnetic field forces sufficient to disrupt the functionality of the pathogen), or a combination of ultrasound and MRI on the exterior of a patient in a desired anatomical region of the patient to assist with the destruction or disabling of a pathogen infecting that anatomical region of the patient, e.g., the patient's lungs, said method being employed at ambient pressures or in an increased or decreased pressure environment created within a hyperbaric chamber. The ultrasound and/or MRI methodologies could also be used to treat other pathogenically afflicted areas of the patient's body. Additionally, a pressure-differential method of sterilization of medical equipment is disclosed employing a hyperbaric or other pressure or vacuum chamber. Also disclosed is an enhanced method of nonsurgical fat reduction in humans by employing ultrasonic cavitation within a hyperbaric chamber, including the use of HBOT therapies. Furthermore, the use of these methodologies and systems have application in treatment of patients post-infection and in other areas of medicine and health, such as for example, treating wounds, the effects of aging, inflammation, and the effects of other maladies.

This invention relates generally to an ultrasound device configured to generate a frustum-shaped beam capable of fragmenting a plurality of biomineralizations located within a patient's body in combination with synthetic cavitation nuclei. The ultrasound device includes a transducer assembly comprising a plurality of ultrasound transducer elements, and a multi-channel amplifier circuit. Each channel of the multi-channel amplifier circuit is configured to actuate a distinct subset of the plurality of transducer elements. The multi-channel amplifier circuit is configured to operate in each of a plurality of states, each state of comprising a set of frequencies at which each channel of the multi-channel amplifier circuit is configured to actuate the distinct subset of transducer elements. The multi-channel amplifier circuit is further configured to switch between the plurality of states, thereby causing the plurality of ultrasound transducer elements to produce a frustum-shaped beam.

The present invention relates to a device, system and a method for high pressure shockwave treatment of biological tissue having a large treatment zone and in particular to such a device, system and method in which a large biological treatment area in treated in a non-drug, non-surgical treatment protocol utilizing ballistic shockwave generating device.

Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.