Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.

A medical device comprising a tube having first segment comprising a primary opening at the proximal end nearest an external termination device; and a second segment comprising a secondary opening at the distal end; and a side-hole dividing the first segment and the second segment, wherein the internal diameter of the first segment is greater than the internal diameter of the second segment, and the tube has no pre-formed curved configuration. The first segment extends from the primary opening to the side-hole and the second segment extends from the side-hole to the secondary opening. The side-hole and first segment form a non-support lumen, and the second segment forms a support lumen. The support lumen is effective to provide stability to the non-support lumen of the tube, to anchor the tube within an anchor area, and to prevent prolapse of the medical device elements due to a counterforce against the tube by the second device(s) being delivered through the tube to a more distal location of a target area; and to facilitate placement of the second medical device into the target area.

A method of using the medical device described.

A minimally invasive endovascular device for treating a blocked or obstructed biological lumen, such as a blood vessel fully or partially obstructed by deposits of biological matters in or non-biological matters. Certain embodiments of the present invention comprise two capture members that are configured to be placed on either side of the obstruction and enclose around the obstruction for removal. Embodiments of the present invention also provide methods for implementing an endovascular device according to aspects of the present invention.

An intraluminal device and a method of removing a clot from a body lumen with an intraluminal device may be provided. The intraluminal device may include a hollow elongated shaft and a radially-expandable mesh segment situated distal to the elongated shaft. The elongated shaft may be secured relative to a first portion of the mesh segment. The intraluminal device may additionally include a core wire affixed to a second portion of the mesh segment and extending through the elongated shaft. The elongated shaft may be configured to radially expand the mesh segment by axially moving the first portion of the mesh segment relative to the second portion of the mesh segment. In addition, the core wire may be configured to radially expand the mesh segment by axially moving the second portion of the mesh segment relative to the first portion of the mesh segment.

A single treatment system for vascular defects can be configured for use in removing clot material via mechanical thrombectomy and/or for deployment of an expandable device at a lesion to treat intracranial atherosclerotic disease (ICAD). Such a treatment system can include a delivery catheter carrying an expandable member configured to be deployed for treatment of ICAD, such as a balloon or balloon-mounted stent. A thrombectomy assembly includes a mechanical thrombectomy device (e.g., a stent retriever) coupled to the distal end of a core member that is slidably disposed within the delivery catheter lumen. In operation, the thrombectomy device can be slidably advanced beyond a distal end of the delivery catheter lumen, where the thrombectomy device can expand and engage clot material. Additionally or alternatively, the expandable member carried by the delivery catheter can be deployed (e.g., expanded into apposition with the vessel wall) for treatment of ICAD.

An endoscope device is provided. The device includes a handle, a steerable sheath, disposed on the handle, and a flexible tube. The device further includes a light source and an image sensor disposed on the flexible tube. The handle includes a passage. The steerable sheath includes a tip, a steerable section, and a lumen. The steerable section of the steerable sheath is actuable to form a bend, such that the tip is operable to be steered toward an anatomical region within a patient. The flexible tube is configured to be inserted within the lumen and the inner passage, such that the light source and the image source are positioned at or near the tip of the steerable sheath. The flexible tube is further configured to be removed from the lumen, such that the lumen is operable to aspirate a bodily object from the anatomical region via the tip.

Disclosed are a thrombectomy device and a thrombectomy system, where the thrombectomy device includes a thrombectomy net, a pushing tube, and a thrombectomy tube, where the thrombectomy tube is provided with a tube cavity, the thrombectomy net has a radial contraction state and a radial expansion state, and a proximal end of the thrombectomy net is fixedly connected to a distal end of the pushing tube. The thrombectomy device further includes an action tube provided with a first action block and a second action block. A distal end of the thrombectomy net is sleeved on the action tube and slides within a limited range of distance between the first action block and the second action block. When relative displacement against the pushing tube occurs, the thrombectomy net is driven to radially contract or expand. Therefore, the contraction and expansion of the thrombectomy net of the present disclosure are controllable.

A minimally invasive endovascular device for treating a blocked or obstructed biological lumen, such as a blood vessel fully or partially obstructed by deposits of biological matters in or non-biological matters. Certain embodiments of the present invention comprise two capture members that are configured to be placed on either side of the obstruction and enclose around the obstruction for removal. Embodiments of the present invention also provide methods for implementing an endovascular device according to aspects of the present invention.

Provided herein are methods and systems for the removal of anatomical occlusions, and an occlusion removal device comprising a first body adapted to be mounted to a delivery wire and releasably engaged to the delivery wire, wherein while engaged the first body remains fixed on the delivery wire and upon release moves axially along the delivery wire, and a second body adapted to be mounted to the delivery wire. A first proximal body may be oriented proximally to a second distal body. The proximal body and the distal body may be adapted to expand upon exiting a delivery catheter. The proximal body may be releasably engaged by a mechanically breakable connection or an electrolytically or heat disconnectable connection, the electrolytically disconnectable connection being broken upon an application of electric current to the electrolytically disconnectable connection.

The present invention relates to a device for ultrasonic-accelerated hematoma lysis or thrombolysis of intracerebral or intraventricular hemorrhages or hematomas, comprising a body which accommodates a number of separated compartments or lumens consisting of a flushing catheter for flushing fluid and/or pharmaceutically active substances into the intracerebral or intraventricular hemorrhages or hematomas, a drainage catheter for draining fluid from the intracerebral or intraventricular hemorrhages or hematomas, an ultrasonic probe duct, and a pressure sensor duct, wherein the compartments or lumens are arranged in proximity to each other and wherein in longitudinal extension at least upper-part sections of the compartments or lumens are isolated by walls, wherein the lumen of the pressure sensor duct integrates a pressure sensor, and wherein in the lumen of ultrasonic probe duct an endosonographic probe or a stiletto is interchangeably guided.