Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

A provided clot extraction system can be used for the removal of clot that may have a wall adherent component. The clot extraction system includes a cover sleeve and a telescoping 5-shaft assembly. A coring element having a blade used for physically breaking down clot is coupled to the shaft assembly. A mesh support element is coupled to the shaft assembly. An open end of a mesh is coupled to the mesh support element and a distal end of the mesh is coupled to the shaft assembly. The mesh is used to collect clot within the vessel, such as the clot that the blade of the coring element separates from the vessel wall. The shape of the coring element or the mesh support element may be altered via the shaft assembly.

A vascular guide wire device comprising: a guide wire comprising a guide wire head and a laser-acoustic head sensor configured to navigate in a patient's blood vessel, said laser-acoustic head sensor connected via an optic fiber threaded through said guide wire device with a laser-acoustic diode controlled by a laser-acoustic diode controller; a computerized system electronically communicating with said laser-acoustic head sensor, said computerized system comprising a computer, image processing means and display means and configured to provide images and measurements 2-centimeters ahead inside a patient's arteries occlusions therein purposing to move and navigate safely into the right artery lumen; first steering means connected with said guide wire head and configured to navigate said laser-acoustic head sensor according to said image processing results; and opening means connected with said guide wire head for opening total occlusion of said artery.