Systems, devices and methods for removing a blood clot (10) from a blood vessel (12). Various uses of suction pressure and positive pressure, proximal and/or distal to the blood clot (10) assist with clot dislodgement and removal. The pressure(s) may be constant and/or cycled/pulsed to assist with clot dislodgement and/or removal. Various further devices assist with separating the clot (10) from the vessel (12).

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Systems, devices and methods treat target tissue to provide a therapeutic benefit to the patient. A tissue treatment device comprises a tissue treatment element constructed and arranged to treat target tissue, such as duodenal mucosa and/or submucosal tissue. Patients treated can safely eliminate or reduce their daily insulin intake.

A catheter has a cannulated guiding rail extending therethrough, an advance segment of the rail extending at least about 10 cm beyond the distal end of the catheter. The catheter and rail are advanced over a guidewire until the distal end of the advance segment is at a target vascular site. The catheter is thereafter advanced along the rail to the target vascular site.

The present invention provides methods and devices for treating endovascular disease. Vibrational energy is delivered to change compliance and increase permeability at the treatment area. To improve clinical outcomes, one or more therapeutic drugs may be delivered to the treatment area.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and/or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

A neurovascular catheter having an angled distal tip has an elongate flexible tubular body with a proximal end, a distal end and a side wall defining a central lumen. The side wall has a helical coil. A tubular jacket surrounds the helical coil, and extending distally beyond the helical coil distal end to terminate in a catheter distal face. A tubular radiopaque marker is embedded in the tubular jacket in between the distal end of the coil and the distal face. The distal face resides on a plane which crosses a longitudinal axis of the tubular body at an angle within the range of from about 35 degrees to about 55 degrees. The marker has a proximal face that is approximately perpendicular to the longitudinal axis and a distal face that resides on a plane which crosses the longitudinal axis at an angle within the range of from about 35 degrees to about 55 degrees.

A catheter has a cannulated guiding rail extending therethrough, an advance segment of the rail extending at least about 10 cm beyond the distal end of the catheter. The catheter and rail are advanced over a guidewire until the distal end of the advance segment is at a target vascular site. The catheter is thereafter advanced along the rail to the target vascular site.

The distal tip of a sensing catheter is placed in proximity to a target intravascular foreign material. A signal is propagated from the sensing catheter, a return signal is received, and at least a portion of the foreign material is captured and removed when the return signal is indicative of a foreign material located within a capture zone.

A system for accessing a central pulmonary artery includes an elongate, flexible tubular catheter, having a proximal end, a distal end and a catheter hub on the proximal end. An elongate, flexible rail has a proximal end, a distal end and a rail hub on the proximal end. The rail has a distal advance segment which extends at least about 10 cm beyond the distal end of the catheter when the catheter hub is adjacent the rail hub.