Controlled delivery of magnetic particles (e.g., nanoparticles) in combination with therapeutic, diagnostic and/or theranostic agents is described. The magnetic particles may be delivered through a catheter to a location adjacent a therapeutic and/or diagnostic target or region.

A system for removing embolic material from an intravascular site is disclosed. The system includes an elongate, flexible tubular body, having a proximal end, a distal end, and a tubular side wall defining at least one lumen extending axially there through; an axial restraint carried by the side wall and exposed to the lumen; a rotatable core wire extendable through the lumen, the core wire having a distal end; a limit carried by the core wire, the limit having a bearing surface for rotatably engaging the restraint; and an agitator tip on the distal end of the core wire. The limit and the restraint are engageable to permit rotation of the core wire but limit distal advance of the tip relative to the tubular body.

A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath. The catheter has an overall length and a distal most section length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

An apparatus includes a delivery catheter having a deployable dynamic valve that dynamically opens and closes in response to relative fluid pressure thereabout, particularly while in an anatomical lumen. The valve is maintained in a collapsed configuration during introduction to a treatment site. The valve is adapted to automatically move from the collapsed configuration to a deployed configuration at the treatment site.

An intracorporeal pressure shock wave includes an expandable pressure shock wave reflector at the distal end of an intracorporeal catheter to direct shock waves from a shock wave generator within a human or animal blood vessel or body lumen.

A neurovascular aspiration catheter has an elliptical distal aspiration port. The catheter has an elongate flexible tubular body comprising a distal port and a side wall defining a central lumen in communication with the port. A tubular radiopaque marker is embedded in the side wall and has a proximal face and a distal face. The distal face of the radiopaque marker inclines at an angle within a range of from about 45 degrees to about 80 degrees relative to the longitudinal axis of the central lumen. The distal port comprises an elliptical opening with an area that is at least about 105% of a cross-sectional area of the central lumen.

A method for thrombus removal within a branched artery includes accessing the branched artery percutaneously; placing a balloon occlusion at a contralateral branch of the branched artery; placing a funneled sheath at the ipsilateral branch of the branched artery; and removing the thrombus mechanically.

A clot removal system comprises a catheter, a vacuum source, and a controller. The catheter comprises a proximal end, a distal end, and controller operating parameters and defines a lumen configured to be filled with a liquid column having a proximal portion. The vacuum source is configured to supply vacuum. The controller is configured to carry out a control pattern of turning on and off the vacuum based upon the controller operating parameters and is configured to receive the controller operating parameters in an automatic response to the catheter being operatively connected to at least one of the vacuum source and the controller and, responsive to the connection, to carry out the control pattern to change a level of vacuum at the distal end of the catheter.

A balloon catheter system and method for clearing blockage in the sinus ostium. The balloon catheter system and method employs a first balloon which dilates the sinus ostium while a second balloon removes an obstruction by resection. The system and method can then remove and/or drain any biological matter in the sinus. In some embodiments, the system employs an imaging device for viewing the anatomy and delivers irrigating and/or therapeutic agents to the sinus and/or sinus ostium.

A mini-invasive device for endourologic treatment includes a tubular conduit, longitudinally flexible, configured to be inserted through and along the operating channel of an endoscope. The tubular conduit internally defines an essentially non-deformable lumen, has a proximal portion having a connector to a suction device, has a distal portion intended to project from the distal tip of the endoscope, and internally delimits a suction conduit, within which at least one tool can be removably inserted to be used in endourologic treatment.