A medical device for removal of an occlusion from a vessel in a patient’s body. The retrieval device having a retriever sub-system and an aspiration sub-system. The retriever sub-system having a delivery catheter and an elongated delivery member that includes proximal and distal expandable elements, the proximal element being removably engaged to the elongated delivery member and the distal element being fixed to the elongated delivery member. The proximal element adapted to move axially along the elongated delivery member in a distal direction toward the distal element when the proximal element is released from the elongated delivery member, whereby, when the proximal element is disposed on a distal side of the vessel occlusion and the distal element is disposed on a proximal side of the occlusion, the proximal and distal elements surround, isolate and contain the occlusion between the proximal and distal elements at the vessel occlusion site. The medical device also includes means for delivering a pharmacological agent composition to the vessel occlusion site during and after the occlusion extraction, the pharmacological agent composition adapted to at least partially lyse and/or disassociate the occlusion from the vessel wall or ameliorate and/or facilitate amelioration of tissue damage to an endothelial luminal wall of an obstructed vessel in vivo and/or enhance the flow rate of blood through the vessel. The aspiration sub-system being in communication with the retriever sub-system and adapted to remove at least a portion of the occlusion from the vessel.

A method for conducting intrabody surgery by means of a surgical device having a cutting arrangement actuated by a driveshaft and rotationally supported by the guide wire. A receiving cannel extends through the cutting arrangement and movably receives the guidewire. A plurality of sensors is provided within the cutting arrangement to emit signals capable of changing parameters depending on the composition of the occlusion, so as to allow the control unit to generate signals controlling operation of the cutting arrangement. The method includes the steps of detecting parameters within the intrabody area by the sensors to controlling operation of the cutting arrangement with the power and control unit.

Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

Rotational atherectomy devices and systems can remove or reduce stenotic lesions in blood vessels by rotating one or more abrasive elements within the vessel. The abrasive elements are attached to a distal portion of an elongate flexible drive shaft that extends from a handle assembly that includes a driver for rotating the drive shaft. In particular implementations, the handle assembly encapsulates an electric motor assembly, a pump assembly, and a controller assembly.

A distal aspiration catheter comprises a catheter body having a central lumen, at least one distal opening and a distal tip positioned distally to the at least one distal opening. An aspiration source is configured to attach to a proximal end/luer hub of the central lumen. When the aspiration source is activated, a clot/emboli lodged in a blood vessel is partially ingested into the at least one distal opening of the catheter body by the application of a static aspiration force. The aspiration source may activate a cyclic aspiration force with a forward pressure flow to induce clot fatigue into the partially ingested clot. The fatigued clot can be collected inside the distal tip of the catheter and be removed completely by a single pass of the distal aspiration catheter.

Rotational atherectomy devices and systems can remove or reduce stenotic lesions in blood vessels by rotating one or more abrasive elements within the vessel. The abrasive elements are attached to a distal portion of an elongate flexible drive shaft that extends from a handle assembly that includes a driver for rotating the drive shaft. In particular implementations, the handle assembly encapsulates an electric motor assembly, a pump assembly, and a controller assembly.

A device and method for establishing retrograde blood flow during recanalization of a vessel having a targeted blockage. While in a collapsed state an occluding component is introduced distally intravascularly traversing the targeted blockage to its distal side. Then, the occluding component transitions to an expanded state having an enlarged diameter forming a seal with an internal wall of the vessel prohibiting anterograde blood flow beyond the expanded occluding component. Retrograde blood flow is thereby established in a region of the vessel bound at one end by the occluding component and at an opposite end by the targeted blockage by dispensing a flushing fluid into the region of the vessel.

Disclosed are methods and devices for bidirectional crossing of a vascular obstruction in a patient. The method includes the steps of advancing a first catheter transvascularly in a first (e.g., retrograde) direction towards a vascular obstruction, the first catheter having a first central lumen in communication with a first side port. A second catheter is advanced transvascularly in a second, opposite (e.g., antegrade) direction towards the obstruction, the second catheter having a second central lumen in communication with a second side port. The first and second side ports are aligned to place the first central lumen in communication with the second central lumen; and a wire is advanced through the first and second side ports such that a first end of the wire is on a first side of the obstruction and a second end of the wire is on a second side of the obstruction.

A medical device configured to perform an endovascular therapy can include an elongate manipulation member and an intervention member. The elongate manipulation member can include a distal end portion. The intervention member can include a proximal end portion and a mesh. The proximal end portion can be coupled with the distal end portion of the elongate manipulation member. The mesh can have a plurality of cells in a tubular configuration and being compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and being self-expandable from the collapsed configuration to an expanded configuration. The mesh can include an anodic metal and a cathodic metal. The anodic metal and the cathodic metal can each form a fraction of a total surface area of the mesh.

The invention generally relates to intraluminal procedures, and, more particularly, to a contra-rotating cutting assembly for use with an atherectomy device to remove occlusive material from an occluded lumen, such as a blood vessel or other body lumen. The contra-rotating cutting assembly includes a rotatable housing having a distal end, an opposing proximal end and a lumen extending between the distal and proximal ends. The housing is configured to rotate about a longitudinal axis in a first direction. The cutting assembly further includes a rotatable cutter head positioned within at least a portion of the lumen of the housing and in coaxial alignment with the housing. The cutter head is configured to rotate about the longitudinal axis in a second direction opposite the first direction.