The present invention relates to a system for the controlled fragmentation of solids by means of acoustic beams, comprising at least one acoustic beam generation unit (100); and one feedback and control unit (200) of said generation unit (100). Advantageously, the acoustic beams generated by the system are acoustic vortex beams; and the feedback and control unit (200) further comprises a feedback subsystem (12), configured to receive the information relating to the fragmented solids and to utilize it so as to adapt the operation of the acoustic beam generation unit (100). Given that the generation of shearing stresses is more efficient using vortex beams, the amplitudes of the ultrasonic field needed to fragment the calculi are much lower than in current extracorporeal shock wave lithotripsy techniques. Likewise, the system minimizes unwanted effects on soft tissues surrounding the solid.

A handheld ultrasound device and corresponding methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. The methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.

A focused extracorporeal shock wave therapy (f-ESWT) device includes a handheld housing, a battery, and a transducer assembly. The battery is located in the handheld housing. The transducer assembly is located in the handheld housing and is operably connected to the battery. The transducer assembly is configured to generate a focused shock wave using electrical energy from the battery.

A focused extracorporeal shock wave therapy (f-ESWT) system includes an f-ESWT device and a plurality of interchangeable standoff structures. The f-ESWT device includes a housing. The f-ESWT device is configured to generate a focused shock wave as a combination of a plurality of individual shock waves. Each standoff structure is configured for removable connection to the housing to receive and to transmit the plurality of individual shock waves. Each standoff structure of the plurality of interchangeable standoff structures includes a rigid exterior shell defining a shell space, and an elastomeric interior at least partially located in the shell space. The plurality of individual shock waves is transmitted through the rigid exterior shell and the elastomeric interior of a selected standoff structure of the plurality of interchangeable standoff structures that is removably connected to the housing.

A focused extracorporeal shock wave therapy (f-ESWT) system includes an f-ESWT device and a plurality of interchangeable standoff structures. The f-ESWT device includes a housing. The f-ESWT device is configured to generate a focused shock wave as a combination of a plurality of individual shock waves. Each standoff structure is configured for removable connection to the housing to receive and to transmit the plurality of individual shock waves. Each standoff structure of the plurality of interchangeable standoff structures includes a rigid exterior shell defining a shell space, and an elastomeric interior at least partially located in the shell space. The plurality of individual shock waves is transmitted through the rigid exterior shell and the elastomeric interior of a selected standoff structure of the plurality of interchangeable standoff structures that is removably connected to the housing.

A method of generating a focused shock wave with a handheld focused extracorporeal shock wave therapy (f-ESWT) device includes driving a plurality of piezoelectric elements to generate a focused shock wave based on a first plurality of time delays when a first standoff structure is removably connected to a handheld housing of the f-ESWT device, and driving the plurality of piezoelectric elements to generate the focused shock wave based on a second plurality of time delays when a second standoff structure is removably connected to the handheld housing of the f-ESWT device, the second plurality of time delays different from the first plurality of time delays, and the second standoff structure different from the first standoff structure.

A method of generating a focused shock wave with a handheld focused extracorporeal shock wave therapy (f-ESWT) device includes driving a plurality of piezoelectric elements to generate a focused shock wave based on a first plurality of time delays when a first standoff structure is removably connected to a handheld housing of the f-ESWT device, and driving the plurality of piezoelectric elements to generate the focused shock wave based on a second plurality of time delays when a second standoff structure is removably connected to the handheld housing of the f-ESWT device, the second plurality of time delays different from the first plurality of time delays, and the second standoff structure different from the first standoff structure.

A method for testing the accuracy and the performance of an ultrasound transducer able to generate cavitation bubbles by placing in a volume of an ultrasound-transmitting medium an elastomer block at an expected cavitation region of the ultrasound transducer, activating the ultrasound transducer so as to generate cavitation bubbles in the elastomer block, detecting in the elastomer marks corresponding to the generated cavitation bubbles and deducing from the marks the three-dimensional characteristics of a real cavitation region of the ultrasound transducer. A system comprising volume of an ultrasound-transmitting medium, an elastomer block disposed in the volume of an ultrasound-transmitting medium, and an ultrasound transducer is also provided.

A method for testing the accuracy and the performance of an ultrasound transducer able to generate cavitation bubbles by placing in a volume of an ultrasound-transmitting medium an elastomer block at an expected cavitation region of the ultrasound transducer, activating the ultrasound transducer so as to generate cavitation bubbles in the elastomer block, detecting in the elastomer marks corresponding to the generated cavitation bubbles and deducing from the marks the three-dimensional characteristics of a real cavitation region of the ultrasound transducer. A system comprising volume of an ultrasound-transmitting medium, an elastomer block disposed in the volume of an ultrasound-transmitting medium, and an ultrasound transducer is also provided.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”