Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

A cannula has a longitudinal base member having a first clamping end and a longitudinal arm member pivotally attached to the longitudinal base member and having a second clamping end, the cannula being in a closed position when the first and second clamping ends are brought together. A first clamp member is located at the first clamping end and has a first passage. A second clamp member is rotatably attached to the arm member at the second clamping end and has a second passage. The first and second passages form a combined passage when the clamp is in the closed position. The cannula may have a first locking member positioned on the arm member and a second locking member positioned on the base member. The first and second locking members interact with each other to lock the cannula in the closed position.

The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

End effectors with closing mechanisms, and related tools and methods may be particularly beneficial when used for minimally invasive surgery. An example surgical tool comprises a first and second jaw movable between a closed grasped or clamped configuration and an open configuration. The tool further comprises a soft grip mode for grasping the tissue at a first force during which a separation parameter between the jaws is measured, and a therapeutic clamping mode in which the jaws clamp on the body tissue at a force greater than the grasping force. The methods comprise grasping the body tissue between jaw members, measuring the separation parameter between jaws, indicating on a user interface the separation parameter for comparison to a desired separation parameter, and then releasing the body tissue for repositioning or therapeutically clamping the body tissue in response to the separation parameter indication.

A system for containment and organization of medical wire features a U-shaped clamp. A first ridged and grooved clamping block is located on a clamp first side posterior end and a second ridged and grooved clamping block is located on a clamp second side posterior end. A first side compression member is located on an inside surface of a clamp first side and a second side compression member is located on an inside surface of the clamp second side. An adjustable ratcheting lock attaches the clamp first side and the clamp second side. A first finger grip is located on an outside surface of the clamp first side and a second finger grip is located on an outside surface of the clamp second side. Medical wire is placed between the first side compression member and the second side compression member then the clamp is compressed against the medical wire.

A clamping mechanism, an instrument cassette, and a sterile isolation plate assembly. The clamping mechanism includes a base plate and a pair of clamping assemblies. Each clamping assembly is fixedly connected to an upper surface of the base plate, has an engaging position and a disengaging position, includes a moving member, at least two clamping members, and several elastic members abutting against respective clamping members. The moving member extends in a front-rear direction and is movable between the engaging and disengaging position. The clamping member includes an upper end portion fixedly connected to or abutting against the moving member and a lower end portion of a hook-shaped structure. The clamping assembly moves from the engaging position to the disengaging position under an action of an external force and compress the corresponding elastic member, and moves from the disengaging position to the engaging position under an action of the elastic member.

Described are surgical clamping devices, which may include a pair of shaft members, each of which may include a jaw member extending from a proximal end of the shaft member and a finger grip extending from an opposing distal end of the shaft member. In addition, each jaw member may include a tip means for holding and clamping a patient's skin along an edge of a wound. The tip means may include at least two pointed teeth that are angled inward and downward from the shaft member. The surgical clamping device may be removed and applied for multiple stages of Mohs micrographic surgery.

Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO to from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.

The invention relates to a reduction forceps comprising a first rod and a second rod, which are supported on a swivel joint defining an axis of rotation such that they are pivotable relative to one another, the first rod comprising on one side of the swivel joint a first jaw and the second rod comprising, on the same side of the swivel joint, a second jaw provided for cooperation with the first jaw, both said jaws having defined thereon contact points for contacting a bone or a bone plate, said contact points being movable in a common pivoting plane, which comprises the swivel joint and in which the axis of rotation extends perpendicularly, and at least one of the jaws being sectionwise displaced in the direction of a plane extending parallel to the pivoting plane.

A surgical instrument for at least partially occlusion of the uterus blood vessels during a cesarean section comprising two jaws movable relative to each other to at least partially occlude the uterus blood vessels, latching mechanism to retain the jaws the in the working position over needed period of time and release the jaws when the need for occlusion is over,

a disposable tubular cover on the end member of each jaw, said end member of a jaw is connected with the other member of the jaw with an angle 25-45 degrees, preferred angle is 30-45 degrees, said cover has an inner cavity open from one end for receiving and retaining the jaw, the thickness of the side of the cover to be engaged with the blood vessels is 3-15 mm, preferably, 8-12 mm, the width of said cover is 10-30 mm, the length of said cover is 50-60 mm, and said cover made of gauze or fabric.