Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a reentry device, and re-entering the true vascular lumen.

A surgical instrument is disclosed including a transducer configured to provide vibrations along a longitudinal axis, an end effector operably coupled to the transducer, and a stationary lower jaw extending parallel to the end effector. The end effector extends along the longitudinal axis. The end effector comprises a blade. The stationary lower jaw comprises a clamp face positioned distal to the blade. The end effector is movable relative to the stationary lower jaw to drive the blade distally towards the clamp face. The end effector comprises a hollow lumen. The end effector further comprises at least one member extended across a portion of the hollow lumen.

Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

There is disclosed, among other things, embodiments of a biopsy needle for taking a full core sample through soft tissue. In the illustrated embodiments, the needle includes a single monolithic tubular member having a notch cut part-way through a distal portion of the tubular member to form an arch-shaped finger. At least a portion of the finger is bent toward the notch and into the lumen of the tubular member. Methods for using these embodiments are also described.

An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Systems and methods are provided for performing a hair transplant using a hair transplant device. The hair transplant device comprises an extraction unit including a coring needle configured to extract at least one hair follicle from a donor site, an implanting unit removably coupled to the extraction unit, the implanting unit including a splitting needle configured to create an opening in a recipient site, a housing coupled to the extraction unit, and a user interface extending from the housing and moveable relative to the housing. The user interface includes a pin movable within the coring needle relative to the housing.

A device for removal of a tissue specimen from a patient includes a housing and a morcellator segment. The device includes a spindle capable of traveling through a longitudinal bore of the housing, and a specimen bag at a distal portion of the housing. In use, the specimen bag is extended from the distal portion of the housing and the spindle passes through the housing and specimen bag, exterior of the specimen bag, thereby forming an opening in the specimen bag. The spindle passes through a tissue specimen, at which point the spindle is retracted to bring the tissue specimen through the specimen bag, and into the longitudinal bore of the housing. The tissue specimen passes through the morcellator segment of the device, whereby the tissue specimen is broken into smaller pieces for ease of removal from the patient's body and further examination.

A method of treating soft tissue conditions. A harvesting device is provided. The harvesting device is operably connected to a tissue processing device using tubing. An aperture is formed in a bone. The bone has an interior. The harvesting device is inserted through the aperture in the bone and into the interior of the bone. The harvesting device is manipulated to dissociate connective tissue progenitor cells in the interior of the bone. Tissue is aspirated from the interior of the bone. The connective tissue progenitor cells are separated from the aspirated tissue. The separated connective tissue progenitor cells are injected in a region of a body that is experiencing a soft tissue condition to treat the soft tissue condition.

Disclosed are methods and devices for endocardial left atrial appendage management (LAAM) by inversion and excision. The methods may comprise inserting an inverter apparatus into an interior cavity of the left atrial appendage (LAA) of a subject and inverting the LAA, closing the base portion of the inverted LAA with the one or more closure devices, separating the inverted LAA from the left atrium with a separation apparatus positioned at the base portion of the inverted LAA adjacent to the one or more closure devices, and removing the separated LAA from the subject.

The present invention relates to a biopsy needle assembly and, more specifically, to a structure of a biopsy needle assembly for reducing a starting load which improves vibration and noise during a procedure and minimizes irritation to a lesion by, when a motor is operated to move a cutter forward/backward while rotating the cutter, stopping motor rotation and reducing an instantaneous load during an initial operation so as to reduce a firing (starting) load of the motor.