The devices and method described herein allow for therapeutic damage to increase volume in these hyperdynamic hearts to allow improved physiology and ventricular filling and to reduce diastolic filling pressure by making the ventricle less stiff. For example, improving a diastolic heart function in a heart by creating at least one incision in cardiac muscle forming an interior heart wall of the interior chamber where the at least one incision extends into one or more layers of the interior heart wall without puncturing through the interior heart wall and the incision is sufficient to reduce a stiffness of the interior chamber to increase volume of the chamber and reduce diastolic filing pressure.

An apparatus for opening or closing a tissue opening in a biological subject, the apparatus including at least two flexible arms coupled to a tissue surface in use, each arm being curved outwardly in a mid-portion to accommodate a tissue opening therebetween and a biasing mechanism that selectively biases opposing ends of each arm to thereby at least one of bias mid-portions of the arms apart to assist in at least partially opening the tissue opening; and bias mid-portions of the arms towards each other to assist in at least partially closing the tissue opening.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Various implementations include a cutting tool for the horizontal incision of tendons. The tool comprises a stem extending along a longitudinal axis, having a distal end, a proximal end and a cutting head, located close to said distal end, having a base plate, having a longitudinal extension axis parallel to the longitudinal axis of the stem, and a blade extending on a plane parallel to the base plate. The blade has a plurality of cutting edges inclined with respect to the longitudinal axis of the cutting head according to different angles, so as to identify at least two vertices defined by two V-shaped profiles.

Various implementations include a cutting tool for the horizontal incision of tendons. The tool comprises a stem extending along a longitudinal axis, having a distal end, a proximal end and a cutting head, located close to said distal end, having a base plate, having a longitudinal extension axis parallel to the longitudinal axis of the stem, and a blade extending on a plane parallel to the base plate. The blade has a plurality of cutting edges inclined with respect to the longitudinal axis of the cutting head according to different angles, so as to identify at least two vertices defined by two V-shaped profiles.

Various implementations include a tool for the subcutaneous cutting of tendons. The tool includes a shaft, arranged along a longitudinal axis, having a proximal end and a distal end, a grip, provided at the proximal end, comprising a fixed handle and a movable trigger, and a cutting head placed at the distal end, which comprises a tendon harvesting tip provided with a groove and a blade. The blade and the harvesting tip are movable relative to each other on a plane which contains the longitudinal axis of the shaft. The blade is inclined with respect to the longitudinal axis of said shaft.

Various implementations include a tool for the subcutaneous cutting of tendons. The tool includes a shaft, arranged along a longitudinal axis, having a proximal end and a distal end, a grip, provided at the proximal end, comprising a fixed handle and a movable trigger, and a cutting head placed at the distal end, which comprises a tendon harvesting tip provided with a groove and a blade. The blade and the harvesting tip are movable relative to each other on a plane which contains the longitudinal axis of the shaft. The blade is inclined with respect to the longitudinal axis of said shaft.

Extraction devices for extracting chronically implanted devices such as leadless cardiac pacemakers (LCP). In some cases, the extraction devices may be configured to cut or tear through at least some of the tissue ingrowth around and/or over the chronically implanted device such that a retrieval feature on the chronically implanted device may be grasped for removal of the chronically implanted device.

Extraction devices for extracting chronically implanted devices such as leadless cardiac pacemakers (LCP). In some cases, the extraction devices may be configured to cut, tear or ablate through at least some of the tissue ingrowth around and/or over the chronically implanted device such that a retrieval feature on the chronically implanted device may be grasped for removal of the chronically implanted device. Implantable medical devices such as LCPs may include features that facilitate their removal.