Method for hydrogenating an ester with molecular hydrogen to the corresponding alcohols in the presence of a ruthenium complex (I), wherein said complex comprises a tridentate ligand L of the general formula (II) ##STR00001##
n and m are each independently 0 or 1, and the solid-dashed double lines represent a single or double bond, with the proviso that in the case of n=1 both solid-dashed double lines represent a single bond and m is 1, and in the case of n=0 one solid-dashed double line represents a single bond and the other solid-dashed double line represents a double bond, wherein in the case of a double bond on the side facing the phenyl ring m=1, in the case of a double bond on the side facing the pyridyl ring m=0, or both solid-dashed double lines represent a single bond and m is 1.

Process P.sup.1 for the manufacture of a secondary fatty alcohol, said process P.sup.1 comprising synthesizing an internal ketone K1 by a process P.sup.0 comprising the decarboxylative ketonization reaction of a fatty acid or the like in a liquid phase with a metal compound as catalyst in a reaction medium, wherein a ketone K.sup.2 at liquid state, which is identical or similar to the internal ketone K.sup.1, is introduced into the reaction medium, and subjecting the internal ketone K.sup.1 to a hydrogenation reaction with hydrogen gas as hydrogenating agent to form the secondary fatty alcohol. Use of the secondary fatty alcohol manufactured by the process P.sup.1 for the manufacture of an internal olefin or of an internal olefin sulfonate.

Process P.sup.1 for the manufacture of a secondary fatty alcohol, said process P.sup.1 comprising synthesizing an internal ketone K1 by a process P.sup.0 comprising the decarboxylative ketonization reaction of a fatty acid or the like in a liquid phase with a metal compound as catalyst in a reaction medium, wherein a ketone K.sup.2 at liquid state, which is identical or similar to the internal ketone K.sup.1, is introduced into the reaction medium, and subjecting the internal ketone K.sup.1 to a hydrogenation reaction with hydrogen gas as hydrogenating agent to form the secondary fatty alcohol. Use of the secondary fatty alcohol manufactured by the process P.sup.1 for the manufacture of an internal olefin or of an internal olefin sulfonate.

The present invention relates to a transition metal complex having a PNNP4 ligand, which is easy to manufacture and handle and is relatively inexpensively available, and a method for manufacturing the same, as well as a method using this transition metal complex as a catalyst for hydrogenation reduction of ketones, esters and amides to manufacture corresponding alcohols, aldehydes, hemiacetals and hemiaminals, a method using this transition metal complex as a catalyst for oxidation of alcohols, hemiacetals and hemiaminals to manufacture corresponding carbonyl compounds, and a method using this transition metal complex as a catalyst for dehydrogenation condensation between alcohols and amines to manufacture alkylamines.

The present invention relates to a transition metal complex having a PNNP4 ligand, which is easy to manufacture and handle and is relatively inexpensively available, and a method for manufacturing the same, as well as a method using this transition metal complex as a catalyst for hydrogenation reduction of ketones, esters and amides to manufacture corresponding alcohols, aldehydes, hemiacetals and hemiaminals, a method using this transition metal complex as a catalyst for oxidation of alcohols, hemiacetals and hemiaminals to manufacture corresponding carbonyl compounds, and a method using this transition metal complex as a catalyst for dehydrogenation condensation between alcohols and amines to manufacture alkylamines.

The present disclosure relates to a process for preparing pitolisant hydrochloride of Formula-(I) and solid-state forms thereof.

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The present disclosure relates to a process for preparing pitolisant hydrochloride of Formula-(I) and solid-state forms thereof.

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The present invention relates to an improved chromium-free Cu—Al catalyst for the hydrogenation of carbonyl groups in organic compounds, characterized in that the catalyst contains zirconium in a proportion of 0.5 to 30.0 wt. %. The invention also relates to the production of the catalyst and to the use of same in the hydrogenation of carbonyl groups in organic compounds.

The present invention relates to an improved chromium-free Cu—Al catalyst for the hydrogenation of carbonyl groups in organic compounds, characterized in that the catalyst contains zirconium in a proportion of 0.5 to 30.0 wt. %. The invention also relates to the production of the catalyst and to the use of same in the hydrogenation of carbonyl groups in organic compounds.

Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.