Methods for total chemical synthesis of Resolvin E1 (RvE1) include Wittig reaction of two compounds having hydroxyl protecting group in the presence of a strong base, removal of the hydroxyl-protecting groups with a deprotecting reagent to produce a compound having an ester group, and hydrolysis of the ester group to obtain RvE1

Described herein is method of making a halogenated partially fluorinated compound, comprising: (a) providing a compound having the following structure of formula (I): R.sub.fCFCXY wherein X and Y are independently selected from F and Cl; wherein R.sub.f is a fluorinated monovalent group comprising 1 to 10 carbon atoms; (b) contacting the compound with at least one of (i) an iodine or bromine containing salt in the presence of an acid; and (ii) aqueous solution of HZ wherein Z is selected from I and Br to form the halogenated partially fluorinated compound of the formula (II): R.sub.fCFHCXYZ wherein X and Y are independently selected from F and Cl; Z is selected from I and Br; and R.sub.f is a fluorinated monovalent group comprising 1 to 10 carbon atoms.

The present invention provides an electrolytic solution capable of providing an electrochemical device (e.g., a lithium ion secondary battery) or a module that is less likely to generate gas even in high-temperature storage and has high capacity retention even after high-temperature storage. The present invention relates to an electrolytic solution which may contain a compound represented by Y.sup.21R.sup.21CCY.sup.22R.sup.22 wherein R.sup.21 and R.sup.22 may be the same as or different from each other, and are each H, an alkyl group, or a halogenated alkyl group; Y.sup.21 and Y.sup.22 may be the same as or different from each other, and are each OR.sup.23 or a halogen atom; and R.sup.23 is H, an alkyl group, or a halogenated alkyl group.

A process for continuous preparation of halogenated alkoxyethane of general formula XCIHCCF.sub.2OR, where X is Cl or F and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XCIHCCYF.sub.2, where each of X and Y is independently Cl or F, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein (a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and (b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent, and (c) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.

A process for continuous preparation of halogenated alkoxyethane of general formula XCIHCCF.sub.2OR, where X is Cl or F and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XCIHCCYF.sub.2, where each of X and Y is independently Cl or F, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein (a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and (b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent, and (c) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.

A process for continuous preparation of halogenated alkoxyethane of general formula XCIHCCF.sub.2OR, where X is Cl or F and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XCIHCCYF.sub.2, where each of X and Y is independently Cl or F, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein (a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and (b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent, and (c) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.

A process for continuous preparation of halogenated alkoxyethane of general formula XClHCCF.sub.2OR, where X is Cl or F and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XClC?CF.sub.2, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent.

A process for continuous preparation of halogenated alkoxyethane of general formula XClHCCF.sub.2OR, where X is Cl or F and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XClC?CF.sub.2, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent.

A process for preparing a low-molecular weight fluoropolyether containing an acid fluoride by decomposing a triflate or trifluoroacetate of a fluoropolyether having a hydroxyl group in the presence of a Lewis acid.

A process for preparing a low-molecular weight fluoropolyether containing an acid fluoride by decomposing a triflate or trifluoroacetate of a fluoropolyether having a hydroxyl group in the presence of a Lewis acid.