A composition comprising a fuel and at least one compound characterized by Formula I:

##STR00001##

wherein X is carbon, oxygen, or sulfur; R.sup.1 and R.sup.2 each independently are hydrogen, a C.sub.1 to C.sub.20 alkyl, or a C.sub.6 to C.sub.10 aryl; R.sup.3 and R.sup.3 each independently are hydrogen or a C.sub.1 to C.sub.4 alkyl; R.sup.4 and R.sup.4 each independently are hydrogen, a C.sub.1 to C.sub.4 alkyl, a C.sub.4 to C.sub.10 cycloalkyl, or a C.sub.6 to C.sub.10 aryl; R.sup.5 and R.sup.5 each independently are a C.sub.4 to C.sub.10 alkyl; R.sup.6 and R.sup.6 each independently are hydrogen or a C.sub.1 to C.sub.6 alkyl; and R.sup.7 and R.sup.7 each independently are hydrogen or a C.sub.1 to C.sub.4 alkyl; and wherein the compound of Formula I when subjected to GC-MS using electron ionization at greater than about 70 eV produces at least one ion having a mass-to-charge ratio of from 300 to 600.

The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.

A polyphenol derivative of the stilbenoid family, namely trans-3,5,4-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.

A composition comprising a fuel and at least one compound characterized by Formula I: ##STR00001##
wherein X is carbon, oxygen, or sulfur; R.sup.1 and R.sup.2 each independently are hydrogen, a C.sub.1 to C.sub.20 alkyl, or a C.sub.6 to C.sub.10 aryl; R.sup.3 and R.sup.3 each independently are hydrogen or a C.sub.1 to C.sub.4 alkyl; R.sup.4 and R.sup.4 each independently are hydrogen, a C.sub.1 to C.sub.4 alkyl, a C.sub.4 to C.sub.10 cycloalkyl, or a C.sub.6 to C.sub.10 aryl; R.sup.5 and R.sup.5 each independently are a C.sub.4 to C.sub.10 alkyl; R.sup.6 and R.sup.6 each independently are hydrogen or a C.sub.1 to C.sub.6 alkyl; and R.sup.7 and R.sup.7 each independently are hydrogen or a C.sub.1 to C.sub.4 alkyl; and wherein the compound of Formula I when subjected to GC-MS using electron ionization at greater than about 70 eV produces at least one ion having a mass-to-charge ratio of from 300 to 600.

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.

An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.