A device and method for improving fertility among couples after intercourse is disclosed. The device and method uses an intravaginal device that collects ejaculate from the vaginal canal after intercourse and presents it to the os of the cervix. The device also serves to contain ejaculate near the cervical os to increase the chances of successful fertilization.

Provided is a fertility device configured to be placed into a subject's vagina after intercourse, the fertility device comprising: a vaginal portion, the vaginal portion comprising: a proximal end; a distal end opposite the proximal end along a longitudinal axis; and a middle portion between the proximal and the distal end; and a lead operatively coupled to the proximal end, wherein: when at least part of the middle portion is placed into a subject's vagina, the lead remains partially outside the vagina, and the vaginal portion impedes leakage of sperm.

A kit having instructions for use for performing uterine lavage in a female patient includes a uterine lavage catheter configured for insertion into a woman's uterus to remove viable blastocysts from the uterus, and one or more first containers having a sufficient dosage amount of a GnRH antagonist to cause desynchronization of the endometrium of the patient prior to, during and/or following recovery of viable blastocysts from the uterus.

A kit having instructions for use for performing uterine lavage in a female patient includes a uterine lavage catheter configured for insertion into a woman's uterus to remove viable blastocysts from the uterus, and one or more first containers having a sufficient dosage amount of a GnRH antagonist to cause desynchronization of the endometrium of the patient prior to, during and/or following recovery of viable blastocysts from the uterus.

The present disclosure provides for systems, methods, and devices for facilitating conception. According to the present disclosure, a conception facilitating device may comprise at least one frame and at least one base. In some embodiments, the at least one frame may be configured to at least partially surround the at least one base. In some aspects, the conception facilitating device may be configured to be insertable into a vaginal canal. The conception facilitating device may be comfortably inserted into a vaginal canal for a period of time, which may increase the possibility of conception.

The present disclosure provides for systems, methods, and devices for facilitating conception. According to the present disclosure, a conception facilitating device may comprise at least one frame and at least one base. In some embodiments, the at least one frame may be configured to at least partially surround the at least one base. In some aspects, the conception facilitating device may be configured to be insertable into a vaginal canal. The conception facilitating device may be comfortably inserted into a vaginal canal for a period of time, which may increase the possibility of conception.

An oocyte retrieval needle is provided. The needle comprises a first tubular region in fluid communication with a second tubular region. The first tubular region comprises a sharp point leading end configured for insertion into a subject. The second tubular region comprises an open trailing end. The leading and trailing ends form respective opposite ends of the needle. Internal passages of the first and second tubular regions form a continuous open passage extending from the leading end to the trailing end. The first tubular region has an outer diameter which is less than an outer diameter of the second tubular region and the internal passage of the first tubular region has an inner, luminal diameter which is less than an inner diameter of the internal passage of the second tubular region. The oocyte retrieval needle is a double lumen needle.

Purified air is provided, having a TVOC content of from less than 5 ppb to about 500 ppb, a Biologicals content of from less than 1 CFU/M.sup.3 to 150 CFU/M.sup.3 and a Particulate content of from about 1,000 0.3 m particles per ft.sup.3 to about 50,000 0.3 m particles per ft.sup.3, or from about 600 0.5 m particles per ft.sup.3 to about 500,000 0.5 m particles per ft.sup.3.

The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.

Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may also be useful in the treatment of infertility associated with PCOS.