Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.

Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.

The present invention provides a spontaneous orientation aid for a liquid crystal composition, containing one kind or two or more kinds of a compound having a partial structure represented by the general formula (i), wherein Z.sup.i1 represents a single bond, etc.; A.sup.i1 represents a divalent 6-membered aromatic group, etc.; m.sup.i1 represents an integer of 1 to 5; and K.sup.i1 represents a structure represented by any of the following formulae (K-1) to (K-8), wherein W.sup.K1 represents a methine group, etc.; X.sup.K1 and Y.sup.K1 each represent CH.sub.2, etc.; Z.sup.K1 represents an oxygen atom, etc.; and U.sup.K1, V.sup.K1, and S.sup.K1 each represent a methine group, etc.:

##STR00001##

The present invention provides a spontaneous orientation aid for a liquid crystal composition, containing one kind or two or more kinds of a compound having a partial structure represented by the general formula (i), wherein Z.sup.i1 represents a single bond, etc.; A.sup.i1 represents a divalent 6-membered aromatic group, etc.; m.sup.i1 represents an integer of 1 to 5; and K.sup.i1 represents a structure represented by any of the following formulae (K-1) to (K-8), wherein W.sup.K1 represents a methine group, etc.; X.sup.K1 and Y.sup.K1 each represent CH.sub.2, etc.; Z.sup.K1 represents an oxygen atom, etc.; and U.sup.K1, V.sup.K1, and S.sup.K1 each represent a methine group, etc.:

##STR00001##

Novel CUR- and CUR-BF.sub.2 compounds exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the -carbonyl moiety as well as CUR-BF.sub.2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF.sub.3, OCF.sub.3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF.sub.2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The compounds and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. Deuterated CUR-BF2 and CUR compounds were also synthesized.

The present invention provides a compound having an excellent rate of change in HTP due to exposure. The present invention further provides a composition formed of the compound, a cured product, an optically anisotropic body, and a reflective film. The compound of the present invention is a compound represented by General Formula (1). ##STR00001##

The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. ##STR00001##

The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.

The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.

Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.