Patent classifications
C07C49/248
Phenol derivatives to treat cancer
The present invention relates to compounds of general formula (I) ##STR00001## wherein R.sup.1-R.sup.8 take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly for the treatment and/or prophylaxis of cancer.
Phenol derivatives to treat cancer
The present invention relates to compounds of general formula (I) ##STR00001## wherein R.sup.1-R.sup.8 take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly for the treatment and/or prophylaxis of cancer.
Half-Curcuminoids as Amyloid-Beta PET Imaging Agents
Provided herein are curcumin analogues that are able to interact with amyloid beta (A) and to attenuate the copper-induced crosslinking of A. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.
PROCESS FOR THE MANUFACTURE OF HYDROXY-SUBSTITUTED AROMATIC COMPOUNDS
The present invention relates to a process for the manufacture of hydroxy-substituted aromatic styryl or stilbene compounds.
PROCESS FOR THE MANUFACTURE OF HYDROXY-SUBSTITUTED AROMATIC COMPOUNDS
The present invention relates to a process for the manufacture of hydroxy-substituted aromatic styryl or stilbene compounds.
PROCESS FOR THE MANUFACTURE OF HYDROXY-SUBSTITUTED AROMATIC COMPOUNDS
The present invention relates to a process for the manufacture of hydroxy-substituted aromatic styryl or stilbene compounds.
ARYL BETA DIKETONES AND THEIR USE AS ODORANTS
The present invention refers to aryl beta diketones of the formula (I)
##STR00001## wherein Y, R.sup.1, R.sup.2 and R.sup.3 have the meaning R.sup.1 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4 alkyl, hydroxyl, methoxy, CF.sub.3 and F; R.sup.2 is selected from the group consisting of methyl and ethyl; R.sup.3 is selected from the group consisting of methyl and ethyl; and Y is a bivalent residue selected from the group consisting of C(O); CH.sub.2CH.sub.2C(O); CR.sup.IR.sup.IIC(O), wherein R.sup.I and R.sup.II are independently selected from hydrogen and methyl; and CHR.sup.IIICHR.sup.IVC(O), wherein R.sup.III and R.sup.IV are independently selected from hydrogen and methyl with the proviso, that R.sup.IIIR.sup.IV are hydrogen or either R.sup.III or R.sup.IV is methyl. The invention further refers to fragrance compositions and fragranced articles comprising them.
ARYL BETA DIKETONES AND THEIR USE AS ODORANTS
The present invention refers to aryl beta diketones of the formula (I)
##STR00001## wherein Y, R.sup.1, R.sup.2 and R.sup.3 have the meaning R.sup.1 is selected from the group consisting of hydrogen, C.sub.1-C.sub.4 alkyl, hydroxyl, methoxy, CF.sub.3 and F; R.sup.2 is selected from the group consisting of methyl and ethyl; R.sup.3 is selected from the group consisting of methyl and ethyl; and Y is a bivalent residue selected from the group consisting of C(O); CH.sub.2CH.sub.2C(O); CR.sup.IR.sup.IIC(O), wherein R.sup.I and R.sup.II are independently selected from hydrogen and methyl; and CHR.sup.IIICHR.sup.IVC(O), wherein R.sup.III and R.sup.IV are independently selected from hydrogen and methyl with the proviso, that R.sup.IIIR.sup.IV are hydrogen or either R.sup.III or R.sup.IV is methyl. The invention further refers to fragrance compositions and fragranced articles comprising them.
SYNTHESIS OF CANNABINOIDS
Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.
SYNTHESIS OF CANNABINOIDS
Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.