The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

A novel fatty acid ester having the general formula R.sup.1COOR.sup.2 wherein R.sup.1 and R.sup.2 are hydrocarbon groups derived from a branched fatty acid and an alcohol, respectively. R.sup.1 is derived from a branched fatty acid which has been refined from a commercially available acid to give a product with a high concentration of monobranched fatty acids and a low concentration of polybranched fatty acids. The use of the ester derived from the refined fatty acid is found to be particularly useful in personal care compositions, for example as an emollient.

A novel fatty acid ester having the general formula R.sup.1COOR.sup.2 wherein R.sup.1 and R.sup.2 are hydrocarbon groups derived from a branched fatty acid and an alcohol, respectively. R.sup.1 is derived from a branched fatty acid which has been refined from a commercially available acid to give a product with a high concentration of monobranched fatty acids and a low concentration of polybranched fatty acids. The use of the ester derived from the refined fatty acid is found to be particularly useful in personal care compositions, for example as an emollient.

The present application relates to a compound of the following formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent independently of each other H or a (C.sub.1-C.sub.30) alkyl group, the total sum of the number of carbon atoms of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, R.sup.5 represents H, OR, or NRR R, R and R, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.

The present application relates to a compound of the following formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent independently of each other H or a (C.sub.1-C.sub.30) alkyl group, the total sum of the number of carbon atoms of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, R.sup.5 represents H, OR, or NRR R, R and R, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.

Disclosed herein is an ophthalmic formulation comprising a compound of formula (I) wherein R.sup.1 is a linear or branched C.sub.9-C.sub.33 alkyl or a linear or branched C.sub.9-C.sub.33 alkenyl with 1 to 4 double bonds; R.sup.2 is a linear or branched C.sub.9-C.sub.19 alkyl or a linear or branched C.sub.9-C.sub.19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.

Disclosed herein is an ophthalmic formulation comprising a compound of formula (I) wherein R.sup.1 is a linear or branched C.sub.9-C.sub.33 alkyl or a linear or branched C.sub.9-C.sub.33 alkenyl with 1 to 4 double bonds; R.sup.2 is a linear or branched C.sub.9-C.sub.19 alkyl or a linear or branched C.sub.9-C.sub.19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.