Disclosed herein are salts of the compound of Formula (I) and polymorphs thereof, methods of making the same, and their methods of use in treating eye diseases and disorders, particularly those associated with inflammation and/or vascular proliferation in subjects. The methods include administering therapeutically effective amounts of salts of the compound of Formula (I) and polymorphic forms thereof, to a subject in need thereof.

Disclosed herein are salts of the compound of Formula (I) and polymorphs thereof, methods of making the same, and their methods of use in treating eye diseases and disorders, particularly those associated with inflammation and/or vascular proliferation in subjects. The methods include administering therapeutically effective amounts of salts of the compound of Formula (I) and polymorphic forms thereof, to a subject in need thereof.

There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.

There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.

A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

Disclosed are methods for separating, recovering, and purifying CBGA, CBDVA, THCVA, CBCVA, and CBCA from dewatered and desolventized crude complex extracts or mixtures of metabolites, cannabinoids, and Cannabis phytochemicals. The methods comprise solubilizing the extracts or mixtures of cannabinoids in a selected solvent, adding a selected amine to precipitate a CBGA-amine or CBDVA-amine or THCVA-amine or CBCVA-amine or CBCA-amine salt therefrom, dissolving the recovered amine salt in a selected solvent, and adding a selected antisolvent to recrystallize a purified amine salt therefrom. The recrystallized amine salt may be decarboxylated to form a mixture of CBG or CBDV or THCV or CBCV or CBC and amine. The cannabinoid and amine mixture may be acidified to separate the amine from CBG or CBDV or THCV or CBCV or CBC. The recovered CBG or CBDV or THCV or CBCV or CBC may then be concentrated.

Provided is a separation recovery method of metal ions and a two-phase separated fluid. The separation recovery method includes mixing a water phase including two or more kinds of metal ions and an organic compound with an oil phase including an extractant to move metal ions belonging to Group 8 to Group 12 from the water phase to the oil phase, the two or more kinds of metal ions including metal ions belonging to Group 3 to Group 16, and the organic compound coordinated to at least one kind of metal ions among the metal ions. In the two-phase separated fluid, a water phase including two or more kinds of metal ions including metal ions belonging to Group 3 to Group 16 and an organic compound and an oil phase including an extractant are phase-separated and present, and metal ions where the extractant is coordinate-bonded to metal elements belonging to Group 8 to Group 12 are present in the oil phase.

The present invention relates to a process for the preparation of amorphous Selexipag from Selexipag crystalline salts using a solvent.

Provided are a water-soluble triarylphosphine for a palladium catalyst, which has high selectivity in a telomerization reaction and is easily recovered with efficiency, an ammonium salt thereof, and a method for efficiently producing the same. Specifically, provided are bis(6-methyl-3-sulphophenyl)(2-methylphenyl)phosphine; a bis(6-methyl-3-sulphonatophenyl)(2-methylphenyl)phosphine diammonium salt obtained by reacting the phosphine with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom; and a method for producing the same.