A method for synthesizing levomethadone hydrochloride including producing (R)-2-(dimethylamino)propan-1-ol by reducing N,N-dimethyl-D-alanine using borax, forming (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochloride by chlorinating the (R)-2-(dimethylamino)propan-1-ol, synthesizing levomethadone nitrile hydrochloride by mixing the (R)-1-chloro-N,N-dimethylpropane-2-amine and diphenylacetonitrile with potassium t-butoxide and producing levomethadone hydrochloride by exposing the levomethadone nitrile hydrochloride to a Grignard reagent.

Provided is a catalyst for amide compound hydrogenation characterized in that rhodium and molybdenum are supported on hydroxyapatite, the catalyst for amide compound hydrogenation providing a catalyst that can promote a reduction reaction that converts an amide compound into an amine compound, can be used under moderate conditions, and has durability that allows repeated use thereof while retaining high activity. Also provided is a method for producing an amine compound, the method being characterized by including bringing an amide compound into contact with the catalyst for amide compound hydrogenation to cause hydrogenation, thereby producing an amine compound.

Provided is a catalyst for amide compound hydrogenation characterized in that rhodium and molybdenum are supported on hydroxyapatite, the catalyst for amide compound hydrogenation providing a catalyst that can promote a reduction reaction that converts an amide compound into an amine compound, can be used under moderate conditions, and has durability that allows repeated use thereof while retaining high activity. Also provided is a method for producing an amine compound, the method being characterized by including bringing an amide compound into contact with the catalyst for amide compound hydrogenation to cause hydrogenation, thereby producing an amine compound.

The present invention provides a method for producing primary amines and secondary amines, the method being characterized by reducing a primary amide or a secondary amide in the presence of a reducing agent and an organic metal halide of a group-2 element.

The present invention provides a method for producing primary amines and secondary amines, the method being characterized by reducing a primary amide or a secondary amide in the presence of a reducing agent and an organic metal halide of a group-2 element.

Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst. Moreover, the inexpensive cobalt-based catalyst can significantly reduce industrialization cost.

Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst. Moreover, the inexpensive cobalt-based catalyst can significantly reduce industrialization cost.

A method for producing a tertiary amine composition that includes the following Steps (1) to (3); Step (1): an amination step of reacting an aliphatic alcohol or an aliphatic aldehyde having 8 or more and 36 or less carbon atoms with dimethylamine in the presence of a metal catalyst; Step (2): a distillation step of separating a reaction liquid obtained through the Step (1) by distillation into a distilled product containing a low-boiling-point compound and a concentrate; and Step (3): a centrifugation step of separating the concentrate obtained through the Step (2) by a centrifugal force into a precipitate and a liquid phase containing the tertiary amine composition.

A method for producing a tertiary amine composition that includes the following Steps (1) to (3); Step (1): an amination step of reacting an aliphatic alcohol or an aliphatic aldehyde having 8 or more and 36 or less carbon atoms with dimethylamine in the presence of a metal catalyst; Step (2): a distillation step of separating a reaction liquid obtained through the Step (1) by distillation into a distilled product containing a low-boiling-point compound and a concentrate; and Step (3): a centrifugation step of separating the concentrate obtained through the Step (2) by a centrifugal force into a precipitate and a liquid phase containing the tertiary amine composition.

A method for producing a tertiary amine composition that includes the following Steps (1) to (3); Step (1): an amination step of reacting an aliphatic alcohol or an aliphatic aldehyde having 8 or more and 36 or less carbon atoms with dimethylamine in the presence of a metal catalyst; Step (2): a distillation step of separating a reaction liquid obtained through the Step (1) by distillation into a distilled product containing a low-boiling-point compound and a concentrate; and Step (3): a centrifugation step of separating the concentrate obtained through the Step (2) by a centrifugal force into a precipitate and a liquid phase containing the tertiary amine composition.