C07C211/42

PROCESS FOR THE PRODUCTION OF (1R,2S)-2,6-DIMETHYL-1-INDANAMINE USING DYNAMIC KINETIC STEREOISOMER RESOLUTION

Process for preparing (1R,2S)-2,6-dimethyl-1-indanamine by dynamic-kinetic stereoisomer cleavage

There is described a process for preparing virtually enantiopure (1R,2S)-2,6-dimethyl-1-indanamine, characterized by reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylation or carboxylation agent in the presence of a protein having the activity of a lipase and carried out under dynamic-kinetic stereoisomer cleavage.