The present invention provides a drug eluting surgical screw and a method for manufacturing a drug eluting surgical screw. The drug eluting surgical screw may include a shaft having a threaded portion, a head having a drive recess disposed at a proximal end of the shaft, the drive recess having a reservoir region and a driver engagement region, and at least one or more drug eluting components disposed within the reservoir region of the drive recess in a manner that does not substantially impair a connection between a driver and the surgical screw when the driver is operably disposed within the driver engagement region, each of the at least one or more drug eluting components including a carrier matrix and a therapeutic agent, the therapeutic agent being at least 20 wt % of the drug eluting component prior to any implantation of the drug eluting surgical screw.

There is a fixation device for promoting fusion and/or osteosynthesis of a first bone segment and a second bone segment, comprising a bone plate portion including an outer surface, an inner surface and at least one fixation aperture extending from the outer surface to the inner surface and a bone wedge portion extending from the plate portion at a first end and a free opposite end, the bone wedge portion comprising a porous architecture configured to promote bone ingrowth, the wedge portion defining first and second engagement surfaces for engaging the first bone segment and a second bone segment, respectively. There is also a method of manufacturing a fixation device for promoting fusion and/or osteosynthesis of a first bone segment and a second bone segment, a method of promoting fusion and/or osteosynthesis of a first bone segment and a second bone segment, and a fixation kit.

The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaestethic can be arranged in one or more compartments (6, 7) which have ifferent release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw. A pusher element (81) can push the deformable body from the sleeve into position on the screw.

A surgical kit includes a shield for covering a portion of the spine of a subject. The shield can include an attachment portion adapted to engage a bone fixation assembly which is adapted to be fixed on multiple vertebra bones of the subject. The bone fixation assembly can include a vertebra joining member secured between two bone anchors. Each bone anchor can include a fastener portion adapted to be implanted into a vertebra bone and a head coupling portion adapted to secure the vertebra joining member. The shield can be coupled to the bone fixation assembly via separate coupling elements, such as a clip or an adjustable link secured between two vertebra joining members of the bone fixation assembly. Alternatively, the shield can include an integral attachment portion configured to engage the bone fixation assembly directly.

A method of increasing movement of a tooth in a jaw having at least one tooth with an orthodontic brace thereon includes: (1) holding a handle of a device, the device having an elongate member extending from the handle and a screw tip at a distal end of the elongate member; (2) moving a sleeve along the elongate member to set a length of exposed screw tip; (3) locking the sleeve in place relative to the screw tip; (4) drilling a hole with the screw tip through a cortical bone of a jaw to increase movement of the tooth; and (5) stopping the drilling when the length of exposed screw tip has penetrated the jaw.

The invention provides a hydrogel for in-vivo release of medication comprising at least one medication, wherein the surface of the hydrogel comprises a coating such that the surface has one or more sub-surfaces with permeability that is at least 2× higher than the average permeability of the entire surface, wherein the hydrogel has an elastic modulus of between 50 and 1000 kPa.

The invention relates to a device for producing a spacer having a stem mold (1) which has an inner space (2), wherein the inner space (2) is accessible via a proximal opening (3) and wherein the stem mold (1) has a proximal wall (4) which peripherally delimits the proximal opening (3) of the stem mold (1), a head mold (5) which has in the interior thereof a hollow space (6), wherein the hollow space (6) has a spherical surface-shaped inner surface (7) and is accessible via a distal opening (8), wherein the head mold (5) has a distal wall (9) which peripherally delimits the distal opening (8) of the head mold (5), a metal core (10) which has a stem part (12), a head part (14) and a flange (16), wherein the flange (16) projects out from the metal core (10), is arranged between the stem part (12) and the head part (14) and has a proximal surface (18) and a distal surface (20), wherein the stem mold (1) and the stem part (12) are shaped such that the stem part (12) is arranged in the inner space (2), when the proximal wall (4) is resting against the distal surface (20), and wherein the head mold (5) and the head part (14) are shaped such that the head part (14) is arranged in the hollow space (6), when the distal wall (9) is resting against the proximal surface (18).

The invention also relates to a set with such a device and to a method for producing spacers with such a device.

The invention relates to an interlocking nail (10) for fixation of transverse and short spiral fractures of, long bone, particularly shaft of the femur, tibia and humerus, having Graft extrusion space/slot (101) for holding stem cells graft and 4 or 5 holes for putting interlocking bolts from lateral to medial direction. Constant compression achieved (irrespective of weight bearing cycle) at the fracture site by tightening of the Endo-Compression Screws (108, 109 and 110) results in stimulation of stem cells and reduction in bone gap, thus enhances bone healing and union manifolds.

For fixedly implanting a device for material or signal delivery or acquisition or a part of such a device in a human or animal body, an opening is provided in hard tissue of the body, the opening reaching through a hard tissue layer, e.g. through a cortical bone layer into cancellous bone underneath. The device includes a plug portion and/or a cover portion which includes a ring of a material having thermoplastic properties extending around the plug portion or on a tissue facing surface of the cover portion. The opening provided in the hard tissue has a cross section at least in the area of its mouth that is adapted to the plug or cover portion such that the plug portion can be introduced through the mouth of the opening or the cover portion can be positioned over the mouth of the opening such that the ring extends around the opening, along its wall and/or on the hard tissue surface around its mouth.

A disposable intramedullary device for temporary use for treatment of limb infections comprising a solid core of variable cross-section, including a distal portion, a middle portion and a proximal portion, said proximal portion and distal portion including anchoring regions consisting of through-holes being passed through by bone anchoring means. Outside said anchoring regions, said solid core is coated with a polymer layer which also includes antibiotic, the outer diameter of the solid core and polymer layer assembly being equivalent to that of an intramedullary channel, and the outer diameter of said solid core in said anchoring regions being equivalent to that of said intramedullary channel.