The present invention provides compositions (e.g., nanoparticles) comprising a conjugated polyethyleneimine (PEI) polymer (a conjugated lipomer), or a pharmaceutically acceptable salt thereof, and a lipid-PEG conjugate, wherein the conjugated lipomer of Formula (I) contains one or more groups of the formula (iii). Compositions of the invention are useful for the delivery of active agents, for example, for the treatment of disease.

N-hydroxyalkylated polyamines, methods of making N-hydroxyalkylated polyamines, and drilling fluids containing N-hydroxyalkylated polyamines are provided, in which the N-hydroxyalkylated polyamine includes Formula (I): ##STR00001##
where R.sup.1 and R.sup.2 are independently a C or CH group; R.sup.3 is an aliphatic hydrocarbyl; R.sup.4 and R.sup.5 are independently acyclic hydrocarbyls, or R.sup.1, R.sup.2, R.sup.4, and R.sup.5 are covalently connected to form a cyclic hydrocarbyl; and R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are independently acyclic hydrocarbyls or acyclic heterohydrocarbyls.

Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and coatings to provide hydrophilic and/or self-cleaning properties.

Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and coatings to provide hydrophilic and/or self-cleaning properties.

Provided are novel compounds of Formula (I):

##STR00001##

and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.

Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

##STR00001##

Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

##STR00001##

The present invention provides a Molybdenum or Tungsten chalcogenide nanoobject having: (a) an object size comprised from 0.1 to 500 nm, and (b) from 1 to 99% by weight of molecules of formula (I) with respect to the total weight of the nanoobject, wherein: A is OH; X is selected from: (C.sub.1-C.sub.20)alkyl optionally substituted with one or more radicals; a 2 to 20-member heteroalkyl optionally substituted with one or more radicals; and a homopolymer or copolymer comprising a polymeric chain; B is selected from: H, OH, NH.sub.2, (C.sub.1-C.sub.4)alkyl, halogen, phenyl substituted with one or more halogen radicals, benzyl substituted with one or more halogen radicals, C(O)R.sub.3, C(O)(R.sub.7), OC(O)(O)R.sub.3, C(O)(O.sup.), C(O)(O)R.sub.3, OR.sub.3, CH(OR.sub.3)(OR.sub.4), C(OR.sub.3)(OR.sub.4)(R.sub.5), C(OR.sub.3)(OR.sub.4)(OR.sub.5), C(OR.sub.3)(OR.sub.4)(OR.sub.5)(OR.sub.6), NR.sub.1R.sub.2, N.sup.+R.sub.1R.sub.2R.sub.3, C(NR.sub.1)(R.sub.2), C(O)(NR.sub.1R.sub.2), N(C(O)(R.sub.1)) (C(O)(R.sub.2))(R.sub.3), O(CN), NC(O), ONO.sub.2, CN, NC, ON(O), NO.sub.2, NO, C.sub.5H.sub.4N, SR.sub.1, SSR.sub.1, S(O)(R.sub.1), S(O)(O)(R.sub.1), S(O)(OH), S(O)(O)(OH), SCN, NCS, C(S)(R.sub.1), PR.sub.1R.sub.2, P(O)(OH).sub.2, OP(O)(OH).sub.2, OP(O)(OR.sub.1)(OR.sub.2), B(OH), B(OR.sub.1)(OR.sub.2), and B(OR.sub.1)(R.sub.2); provided that when B is H or (C.sub.1-C.sub.4) alkyl, then X is a homopolymer, a copolymer, or a 2 to 20-member heteroalkyl optionally substituted with one or more radicals as defined above.

The present invention also provides processes for the preparation of the nanoobjects, their use as additive for reducing the friction coefficient of a material, and compositions comprising thereof.

A-X-B(I)

The present invention provides a Molybdenum or Tungsten chalcogenide nanoobject having: (a) an object size comprised from 0.1 to 500 nm, and (b) from 1 to 99% by weight of molecules of formula (I) with respect to the total weight of the nanoobject, wherein: A is OH; X is selected from: (C.sub.1-C.sub.20)alkyl optionally substituted with one or more radicals; a 2 to 20-member heteroalkyl optionally substituted with one or more radicals; and a homopolymer or copolymer comprising a polymeric chain; B is selected from: H, OH, NH.sub.2, (C.sub.1-C.sub.4)alkyl, halogen, phenyl substituted with one or more halogen radicals, benzyl substituted with one or more halogen radicals, C(O)R.sub.3, C(O)(R.sub.7), OC(O)(O)R.sub.3, C(O)(O.sup.), C(O)(O)R.sub.3, OR.sub.3, CH(OR.sub.3)(OR.sub.4), C(OR.sub.3)(OR.sub.4)(R.sub.5), C(OR.sub.3)(OR.sub.4)(OR.sub.5), C(OR.sub.3)(OR.sub.4)(OR.sub.5)(OR.sub.6), NR.sub.1R.sub.2, N.sup.+R.sub.1R.sub.2R.sub.3, C(NR.sub.1)(R.sub.2), C(O)(NR.sub.1R.sub.2), N(C(O)(R.sub.1)) (C(O)(R.sub.2))(R.sub.3), O(CN), NC(O), ONO.sub.2, CN, NC, ON(O), NO.sub.2, NO, C.sub.5H.sub.4N, SR.sub.1, SSR.sub.1, S(O)(R.sub.1), S(O)(O)(R.sub.1), S(O)(OH), S(O)(O)(OH), SCN, NCS, C(S)(R.sub.1), PR.sub.1R.sub.2, P(O)(OH).sub.2, OP(O)(OH).sub.2, OP(O)(OR.sub.1)(OR.sub.2), B(OH), B(OR.sub.1)(OR.sub.2), and B(OR.sub.1)(R.sub.2); provided that when B is H or (C.sub.1-C.sub.4) alkyl, then X is a homopolymer, a copolymer, or a 2 to 20-member heteroalkyl optionally substituted with one or more radicals as defined above.

The present invention also provides processes for the preparation of the nanoobjects, their use as additive for reducing the friction coefficient of a material, and compositions comprising thereof.

A-X-B(I)

A method efficiently and safely manufactures, on an industrial scale, a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group. (1) an amine compound or a solution thereof, (2) epichlorohydrin or a solution thereof, and (3) an acidic compound or a solution thereof are continuously supplied to a flow reactor and reacted at a reaction temperature of 40 to 130 C. and a liquid space velocity of 0.2 to 10 h.sup.1 so that a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group is manufactured. The obtained compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group is dehydrochlorinated by reaction with an alkali so that a polyfunctional glycidylamine type epoxy compound is manufactured.