The present invention relates to salts of budesonide 21-phosphate with β2 adrenergic agonists, preferably with formoterol, pharmaceutical compositions containing the same and the use thereof in the treatment of respiratory inflammatory pathologies, obstructive pathologies and allergen-induced airway dysfunctions. The invention further relates to the process for preparing said salts.

Disclosed herein are FABP4 and FABP5 inhibitor compounds and their use in pharmaceutical compositions for treating diseases relating to fatty acid metabolism, including cancer. Also disclosed herein are methods for preparing the disclosed compounds.

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.

A method for producing acetaminophen may include causing p-nitrophenol to undergo an acetamination reaction to produce the acetaminophen, by passing a solution containing the p-nitrophenol through a column packed with a catalyst while also passing an acetylating agent and hydrogen through the column. The catalyst may be a supported metal catalyst in which a metal element is supported on a synthetic adsorbent, and a reaction temperature of the acetamination reaction is 0° C. to 60° C., and a reaction pressure of the acetamination reaction is 0.1 MPa to 1 MPa. With the method, it is possible to continuously produce acetaminophen safely and inexpensively with high selectivity and good yield, at a low reaction temperature and a low reaction pressure.

A method for producing acetaminophen may include causing p-nitrophenol to undergo an acetamination reaction to produce the acetaminophen, by passing a solution containing the p-nitrophenol through a column packed with a catalyst while also passing an acetylating agent and hydrogen through the column. The catalyst may be a supported metal catalyst in which a metal element is supported on a synthetic adsorbent, and a reaction temperature of the acetamination reaction is 0° C. to 60° C., and a reaction pressure of the acetamination reaction is 0.1 MPa to 1 MPa. With the method, it is possible to continuously produce acetaminophen safely and inexpensively with high selectivity and good yield, at a low reaction temperature and a low reaction pressure.

A continuous paracetamol preparation method, including a nitration step or a nitrosation step to obtain p-nitrophenol or p-nitrosophenol respectively. P-nitrophenol or p-nitrosophenol can then be converted into paracetamol by hydrogenation, followed by acylation. This continuous paracetamol preparation method makes it possible to obtain paracetamol with a very good regioselectivity and excellent yields.

A continuous paracetamol preparation method, including a nitration step or a nitrosation step to obtain p-nitrophenol or p-nitrosophenol respectively. P-nitrophenol or p-nitrosophenol can then be converted into paracetamol by hydrogenation, followed by acylation. This continuous paracetamol preparation method makes it possible to obtain paracetamol with a very good regioselectivity and excellent yields.

Novel 2,2′-diaminobiaryls having two secondary amines and an electrochemical process for preparation thereof.

Novel 2,2′-diaminobiaryls having two secondary amines and an electrochemical process for preparation thereof.