The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi):

##STR00001##

wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl.

The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi):

##STR00001##

wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl.

The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VI): ##STR00001##
wherein: R.sub.1 is H, Cl, F, —CF.sub.3, —OCF.sub.3, —OMe, or methyl; R.sub.8 is selected from the group consisting of: —NH.sub.2, —N(H)Alk, —N(Alk).sub.2, ##STR00002## R.sub.7 is H or alkyl; m is 3 to 6; p is 1 to 4; q is 1 to 4; p+g is 3 to 6; and each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms,
and methods of making and using same.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VI): ##STR00001##
wherein: R.sub.1 is H, Cl, F, —CF.sub.3, —OCF.sub.3, —OMe, or methyl; R.sub.8 is selected from the group consisting of: —NH.sub.2, —N(H)Alk, —N(Alk).sub.2, ##STR00002## R.sub.7 is H or alkyl; m is 3 to 6; p is 1 to 4; q is 1 to 4; p+g is 3 to 6; and each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms,
and methods of making and using same.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): ##STR00001## wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIm), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIm), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIm) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): ##STR00001## wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIm), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIm), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIm) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIg):

##STR00001##

wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl.

The present disclosure further provides methods of making compounds of general formula (VIIIg), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIg), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIg) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIg):

##STR00001##

wherein: R.sub.2=H or Me; R.sub.3=H or Me; R.sub.4=Alkyl; R.sub.5=O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl.

The present disclosure further provides methods of making compounds of general formula (VIIIg), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIg), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIg) to the subject.

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.