Compounds for the chemosensitization of antibiotic resistant bacteria such as multidrug resistant (MDR) Pseudomonas aeruginosa (Pa) are provided. The compounds inhibit the MDR efflux proteins and re-sensitize the bacteria towards killing by antibiotics. Thus, the compounds are used in combination with antibiotics to treat or prevent infections caused by MDR bacteria.

Compounds for the chemosensitization of antibiotic resistant bacteria such as multidrug resistant (MDR) Pseudomonas aeruginosa (Pa) are provided. The compounds inhibit the MDR efflux proteins and re-sensitize the bacteria towards killing by antibiotics. Thus, the compounds are used in combination with antibiotics to treat or prevent infections caused by MDR bacteria.

Compounds for the chemosensitization of antibiotic resistant bacteria such as multidrug resistant (MDR) Pseudomonas aeruginosa (Pa) are provided. The compounds inhibit the MDR efflux proteins and re-sensitize the bacteria towards killing by antibiotics. Thus, the compounds are used in combination with antibiotics to treat or prevent infections caused by MDR bacteria.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi): ##STR00001##
wherein: R.sub.2H or Me; R.sub.3H or Me; R.sub.4=Alkyl; R.sub.5O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi): ##STR00001##
wherein: R.sub.2H or Me; R.sub.3H or Me; R.sub.4=Alkyl; R.sub.5O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (XIII): ##STR00001##
wherein: R.sub.8=NH.sub.2, NH(Me), N(Me).sub.2, ##STR00002## The present disclosure further provides methods of making compounds of general formula (XIII), compositions comprising a therapeutically effective amount of a compound of general formula (XIII), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (XIII) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (XIII): ##STR00001##
wherein: R.sub.8=NH.sub.2, NH(Me), N(Me).sub.2, ##STR00002## The present disclosure further provides methods of making compounds of general formula (XIII), compositions comprising a therapeutically effective amount of a compound of general formula (XIII), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (XIII) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): ##STR00001##
wherein: R.sub.2H or Me; R.sub.3H or Me; R.sub.4=Alkyl; R.sub.5O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIk), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIk), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIk) to the subject.

The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): ##STR00001##
wherein: R.sub.2H or Me; R.sub.3H or Me; R.sub.4=Alkyl; R.sub.5O-Alkyl; and Alkyl=aliphatic C.sub.1-C.sub.4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIk), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIk), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIk) to the subject.

A catalyst represented by General Formula (1) below:

##STR00001## where in the General Formula (1), R.sup.1 to R.sup.14 each independently represent a hydrogen atom or a substituent.