The present disclosure provides compositions comprising one or more compounds of general formula (I): ##STR00001##
wherein: R.sub.1 is H, OMe, Me, or one or more electron withdrawing groups; R.sub.2 and R.sub.3 are each independently H or alkyl or, taken together, form a 4- to 8-membered heterocyclic ring with the adjacent nitrogen atom; R.sub.4 is H or alkyl; R.sub.5 is H or one or more electron donating groups; and n is 1 to 4.

The present disclosure provides compositions comprising one or more compounds of general formula (I): ##STR00001##
wherein: R.sub.1 is H, OMe, Me, or one or more electron withdrawing groups; R.sub.2 and R.sub.3 are each independently H or alkyl or, taken together, form a 4- to 8-membered heterocyclic ring with the adjacent nitrogen atom; R.sub.4 is H or alkyl; R.sub.5 is H or one or more electron donating groups; and n is 1 to 4.

The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-? in a subject.

The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-? in a subject.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) ##STR00001##
characterized in that
anilides of the formula (II) ##STR00002##
in a solvent other than tetrahydrofuran,
are reacted with an organoboron compound of the formula (III) ##STR00003##
in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) ##STR00001##
characterized in that
anilides of the formula (II) ##STR00002##
in a solvent other than tetrahydrofuran,
are reacted with an organoboron compound of the formula (III) ##STR00003##
in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) ##STR00001## characterized in that anilides of the formula (II) ##STR00002## in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III) ##STR00003## in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) ##STR00001## characterized in that anilides of the formula (II) ##STR00002## in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III) ##STR00003## in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

The present invention relates to a compound represented by the general formula (I) (wherein the definition of each group has the same meaning as described in the specification). The compound is useful as preventive and/or therapeutic agent for KCNQ2-5 channel-related diseases. ##STR00001##