A process of dissolving ##STR00001##
in a solvent to produce a first mixture. To the first mixture a reagent is added to produce a second mixture. A HNRR is then added to the second mixture to produce a third mixture. The third mixture is then refluxed to produce ##STR00002##

A process of dissolving ##STR00001##
in a solvent to produce a first mixture. To the first mixture a reagent is added to produce a second mixture. A HNRR is then added to the second mixture to produce a third mixture. The third mixture is then refluxed to produce ##STR00002##

A process of dissolving ##STR00001##
in a solvent to produce a first mixture. To the first mixture a reagent is added to produce a second mixture. A HNRR is then added to the second mixture to produce a third mixture. The third mixture is then refluxed to produce ##STR00002##

The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention provides compounds, compositions thereof, and methods of using the same.

The invention relates to a kind of medicinal salts of polyamine derivatives, preparation method and use thereof in preparation of a drug for treating sepsis. These novel compounds have good antagonistic action on a plurality of pathogen-associated molecular patterns that induce sepsis, such as bacterial lipopolysaccharide (endotoxin), bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan, and can be used for preparation of a drug for treating sepsis.

This invention relates to a wax composition comprising a plurality of fatty acid amide compounds having the Formula (I):

##STR00001##

where R.sup.1, R.sup.2, n.sub.1, n.sub.2, m.sub.1, and m.sub.2 are as described herein. This invention also relates to a wax composition comprising: a) one or more fatty acid amide compounds having the Formula (II):

##STR00002##

and b) one or more fatty acid amide compounds having the Formula (III):

##STR00003##

where R.sup.1, R.sup.2, n.sub.1, and n.sub.2 are as described herein. This invention also relates to a fatty acid amide compound having the Formula (I) and a process for preparing a compound of Formula (I).

Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an active activation instead of a passive activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.

A personal care composition comprising N-aralkylcarbonyldiamines. When such compounds are used in personal care compositions, they have been unexpectedly shown to enhance cell proliferation and epidermal thickness, traits associated with younger, healthy looking skin.