Novel 2,2-diaminobiaryls having two secondary amines and an electrochemical process for preparation thereof.

A first tire member manufacturing method includes an operation in which a master batch is made, and an operation in which the master batch, peptizing agent, and processing additive are mixed. The operation in which the master batch is made includes an operation in which carbon-black-containing pre-coagulation rubber latex is coagulated to obtain a coagulum, an operation in which a compound according to Formula (I), below, is added to the water-containing coagulum, and an operation in which the compound according to Formula (I) is dispersed within the coagulum. ##STR00001## In Formula (I), R.sup.1 and R.sup.2 each indicates a hydrogen atom, an alkyl group having 1 to 20 carbons, an alkenyl group having 1 to 20 carbons, or an alkynyl group having 1 to 20 carbons. R.sup.1 and R.sup.2 may be the same or different. M.sup.+ indicates sodium ion, potassium ion, or lithium ion.

A first tire member manufacturing method includes an operation in which a master batch is made, and an operation in which the master batch, peptizing agent, and processing additive are mixed. The operation in which the master batch is made includes an operation in which carbon-black-containing pre-coagulation rubber latex is coagulated to obtain a coagulum, an operation in which a compound according to Formula (I), below, is added to the water-containing coagulum, and an operation in which the compound according to Formula (I) is dispersed within the coagulum. ##STR00001## In Formula (I), R.sup.1 and R.sup.2 each indicates a hydrogen atom, an alkyl group having 1 to 20 carbons, an alkenyl group having 1 to 20 carbons, or an alkynyl group having 1 to 20 carbons. R.sup.1 and R.sup.2 may be the same or different. M.sup.+ indicates sodium ion, potassium ion, or lithium ion.

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

The present invention relates to compounds of general formula (I) ##STR00001## and pharmaceutically acceptable salts thereof; wherein R1-R11, L, Z, Y, and Z are as defined in the claims. The invention also relates to said compounds for use as a medicament and particularly in the treatment of traumatic brain injury.

The present invention relates to compounds of general formula (I) ##STR00001## and pharmaceutically acceptable salts thereof; wherein R1-R11, L, Z, Y, and Z are as defined in the claims. The invention also relates to said compounds for use as a medicament and particularly in the treatment of traumatic brain injury.

The present invention provides a rubber composition obtained by kneading a compound represented by the formula (I), a rubber component and a filler, and the like:

##STR00001##

wherein the groups in the formula (I) are as described in the DESCRIPTION.

The present invention provides a rubber composition obtained by kneading a compound represented by the formula (I), a rubber component and a filler, and the like:

##STR00001##

wherein the groups in the formula (I) are as described in the DESCRIPTION.

The invention provides methods of treating Friedreich's ataxia and other neurodegenerative or neuromuscular conditions using histone deacetylase inhibitors.

The invention provides methods of treating Friedreich's ataxia and other neurodegenerative or neuromuscular conditions using histone deacetylase inhibitors.