Device, systems, and methods for cryoablation are described herein. In some implementations, the devices and systems are used to for cryoneurolysis or cryoablation of nerves. An example cryoablation probe includes a tubular member having a proximal end and a distal end. The tubular member has a probe tip arranged at the distal end. The probe also includes one or more energy elements arranged along an axial direction of the tubular member, and one or more sensor elements arranged along the axial direction of the tubular member.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

A system for performing a cryoablation treatment may include at least one computing device configured to obtain temperature information at a plurality of heating locations on a cryo-fluid supply. The plurality of heating locations includes a first heating location and a second heating location. The computing device is also configured to compare a first temperature at the first heating location to an expected first temperature and to initiate a first heating cycle at the first heating location if the first temperature at the first heating location is less than the expected first temperature. The computing device also compares a second temperature at the second heating location to an expected second temperature wherein the second heating location disposed downstream of the first heating location and initiates a second heating cycle at the second heating location if the second temperature is less than the expected second temperature.

A system to perform cryoablation treatments includes at least one computing device configured to obtain at least one impedance measurement from a cryoprobe and determine whether a bleeding condition is present at a treatment site proximate the cryoprobe based on the at least one impedance measurement. The at least one computing device also adjusts one or more inputs to a heater in the cryoprobe when the at least one impedance measurements indicate that the bleeding condition is present.

Compositions, systems, devices, and methods for performing precise chemical treatment of tissues are disclosed. Systems, devices, and methods for administering a chemical agent to one or more a precise regions within a tissue mass are disclosed. Compositions, systems, devices, and methods for treating targeted regions within a tissue mass are disclosed. Systems, devices, and methods for identifying, localizing, monitoring neural traffic in the vicinity of, quantifying neural traffic in the vicinity of, and mapping neural traffic near targeted regions within a tissue mass are disclosed.

A cryosurgical instrument, in particular a biopsy instrument for transbronchial biopsy, having an elongated instrument base body with a distal and proximal end, in relation to the operational position, a cooled section close to the distal end and which removes tissue, said section being designed such that surrounding biological material adheres thereto, by means of cryoadhesion, when said instrument is in use in the cooled state, and a security section which is provided at a distance from the tissue removal section and which comprises means for preventing or reducing the adhesion of biological material.

A method includes attaching one or more heat exchangers to one or more of a distal handle end and a proximal handle end of a lithotripter, the lithotripter including a handle, the handle having a handle distal end and a handle proximal end; a probe housed within the handle, the probe having a probe distal end and a probe proximal end; a passageway extending through the handle at least partially containing the probe; and a shielding insert contained within the passageway; wherein the probe, the passageway, and the shielding insert are contained within a central lumen of a driver resource; and performing a sterilization procedure on the surgical device; wherein the one or more heat exchangers collect and transfer heat at least through a full length of the handle, particularly to the lumen contained within the handle.

A slurry is injected into a subject at a treatment site selected from the group consisting of (i) a deep subcutaneous fat layer, (ii) a superficial subcutaneous fat layer, and (iii) the deep subcutaneous fat layer and the superficial subcutaneous fat layer. Fat cells in the selected treatment site are ablated by the slurry. For example, the slurry is injected into (i) the deep subcutaneous fat layer only, (ii) the superficial subcutaneous fat layer only, (iii) the deep subcutaneous fat layer followed by the superficial subcutaneous fat layer, (iv) the superficial subcutaneous fat layer followed by the deep subcutaneous fat layer, or (v) the deep subcutaneous fat layer and the superficial subcutaneous fat layer simultaneously.

Systems and techniques for a medical apparatus, specifically a handheld electrosurgical device, are described herein. In an example, the device includes an electrosurgical end effector, a temperature sensor to measure a temperature of the end effector, a cooler to cool the end effector based on the measured temperature, and a heater to heat the end effector based on the measured temperature. The end effector may be kept within a temperature range or band such as by allowing the end effector to be heated or cooled as desired during a surgical procedure.

Flexible apparatus for ablating unhealthy spinal tissue. A housing includes a distal end and a proximal end. Multiple thermocouples mounted on the housing measure spinal tissue temperatures at locations between the proximal end and the distal end. A sensor measures spinal tissue impedance. The measured spinal tissue impedance corresponds to various physical state data of the spinal tissue. The spinal tissue impedance and the spinal tissue temperatures are displayed to the surgeon, enabling the surgeon to determine with certainty the location of the unhealthy spinal tissue, and to exercise control over the ablation apparatus. Nerve stimulation by IMP/STM switch system to detect nerve responses before and after treatment.