A medical device includes a capacitive micromachined ultrasonic transducer (CMUT) array configured to emit ultrasound to target tissue, and at least one thermoelectric cooler mechanically coupled with the CMUT array and configured to cool non-target tissue heated by the ultrasound. The medical device may be implemented in a catheter together with a solid thermal conductor coupled to the thermoelectric cooler and extending along the catheter, to conduct heat away from the thermoelectric cooler. A catheter or catheter sleeve includes a tubular wall for insertion into a body channel, and at least one thermoelectric cooler coupled to the tubular wall for cooling the body channel wall. A catheter sleeve includes tubular casing for insertion into a body channel and capable of encasing a catheter, and at least one sensor coupled to the tubular casing for sensing one or more properties of the body channel wall, such as temperature and pressure.

An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

The skin treatment device that generates high intensity pulses of broadband light and includes a body, a light source to deliver light energy pulses, a control system to control the light source to deliver the light energy pulses, a primary lightguide including a solid material defining a first skin contact surface for guiding light energy to the skin of a subject, a cooling arrangement to cool the solid material, and a head configured to be mountable and demountable to the body. The device is operable in a first operable configuration with the head demounted from the body and a second operable configuration where the head is mounted to the body. In the second operable configuration, the first skin contact surface is spaced apart from the subject's skin and the light energy pulses pass through both the solid material and a light energy pulse transmission channel of a secondary lightguide.

A fluid cooling system for cooling a microwave antenna includes an energy source configured to supply microwave energy to a microwave antenna for ablating tissue, a fluid source, a centrifugal pump, and a cooling member coupled to the centrifugal pump and configured to contact the tube to cool fluid flowing through the tube.

Systems for treating a subject's tissue can include a thermally conductive cup with vacuum features configured to facilitate removal of air located between the cup and the subject's skin. The vacuum features can extend along cup to provide airflow paths to a vacuum port. The applicator can cool and/or heat the retained tissue to affect targeted tissue. After the treat period, the vacuum can be reduced or stop and the applicator can be removed from the subject.

Devices, systems, and methods for implanting and locating traceable markers in a region of a patient's body such as a lung, and in particular lung nodules which may be difficult to locate using traditional means. Further embodiments describe devices, systems, and methods that may be used to treat regions in the lung such as lung nodules with various treatment modalities including heating, microwave irradiation, chemical treatment, and which may be used in conjunction with embodiments of the traceable markers described herein.

A method of treating abnormal tissue within a patient includes positioning a delivery cannula within the patient, the delivery cannula having a first electrode disposed on its distal end; introducing an ablation probe through the cannula and out an open distal end thereof, so that a second ablation electrode carried on the ablation probe contacts abnormal tissue within the patient; conveying ablation energy between the first and second ablation electrodes to ablate the abnormal tissue; and introducing a separate medical element, whether a device or a therapeutic agent, through the cannula before or after the ablation process.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

An electrosurgical device is provided. The device includes a cooled probe, an introducer, and a side port for the introduction of liquid into a lumen defined by an outer diameter of the probe and an inner diameter of the introducer when the probe is positioned inside the introducer such that a distal end of the probe can contact a target site (e.g., the site near/adjacent the tissue to be treated). The side port can be connected to a syringe/other liquid introduction apparatus via tubing so that a liquid (e.g., a therapeutic agent, saline, etc.) can be injected into the lumen and can exit the distal region of the introducer so that it is delivered to the target site. Additionally, the syringe can be removed so that the tubing can serve as a vent during treatment with the electrosurgical device.