A cryoablation catheter includes an inner lumen and an inflatable balloon surrounding the inner lumen. An inflow pipe is disposed within the inflatable balloon and is configured to introduce a refrigerant into the balloon. A thermocouple wire is disposed within the inflatable balloon and positioned adjacent the inflow pipe. The thermocouple wire is configured to measure an internal temperature of the balloon. The cryoablation catheter further includes an isolation guide disposed within the inflatable balloon. The isolation guide includes a central bore configured to receive the inner lumen, an inflow bore configured to receive the inflow pope, and a thermocouple bore configured to receive the thermocouple wire. The thermocouple bore is spaced from the inflow bore along the isolation guide.

An example medical system for ablating and occluding the left atrial appendage is disclosed. The example system includes a catheter sized and shaped for vascular access and including an elongate body extending between a proximal end and a distal end. A first expandable member may be positioned near the distal end of the elongate body and have a first region configured to permeate a liquid therethrough. A first set of one or more electrodes may be arranged within the first expandable member and may be configured to deliver energy to the tissue region. An occlusive implant may be releasably secured to the distal end of the elongate body.

In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

An electrosurgical system for puncturing tissue includes an electrosurgical generator configured to generate radiofrequency (RF) energy and a crossing device connected to the electrosurgical generator. The crossing device includes an electrode positioned at a distal tip of the crossing device, wherein the electrode has a surface texture that is configured to form and hold a gaseous insulation layer that is formed when the crossing device is positioned in an electrically conductive liquid medium and is energized by the electrosurgical generator.

A surgical device is disclosed herein that can include an end effector including a clamp jaw, a trigger configured to open and close the clamp jaw, a sensor configured to detect a relative position of the trigger, and a control circuit communicably coupled to the sensor and a generator. The control circuit is configured to cause the generator to administer energy associated with a surgical operation to be performed on the tissue, receive a signal from the sensor, determine that the clamp jaws are not positioned to administer the energy associated with the surgical operation, and cause the generator to administer energy configured to release the tissue from an ultrasonic blade. The energy is configured to release the tissue from the clamp jaw is different than the energy associated with a surgical operation to be performed on the tissue.

A deployable invasive device includes a transducer with a plurality of elements with linked by at least one shape memory material, the at least one shape memory material configured to move the plurality of the elements relative to one another between a first configuration and a second configuration in response to the thermal stimulus. The shape memory material comprises at least one active region configured to change shape to facilitate transition between the first configuration and the second configuration. The deployable invasive device further includes at least one integral heating resistor on or within the at least one active region and configured to heat the shape memory material surrounding the integral heating resistor to provide the thermal stimulus.

An example medical system for ablating and occluding the left atrial appendage is disclosed. The example system includes a catheter sized and shaped for vascular access and including an elongate body extending between a proximal end and a distal end. A first expandable member may be positioned near the distal end of the elongate body and have a first region configured to permeate a liquid therethrough. A first set of one or more electrodes may be arranged within the first expandable member and may be configured to deliver energy to the tissue region. An occlusive implant may be releasably secured to the distal end of the elongate body.

An electrode apparatus for nerve denervation or modulation in vivo includes a main body including a shaft; an electrode unit formed to be drawn out from one end of the shaft and configured to denervate or modulate at least some of nerves on a tube in the body; an electrode guide including a plurality of joint units and a wire connecting the plurality of joint units to each other and configured to guide the electrode unit; and a driving unit located inside the main body and configured to drive the joint units and the wire to protrude from the one end of the shaft. The driving unit drives the joint units in conjunction with the wire to have different displacements by using a gear ratio between two rack gears depending on a pitch circle diameter ratio between two pinion gears.