Embodiments herein relate to systems and methods for endoscopic ultrasound-guided celiac plexus ablation and sensing. In an embodiment, a system for endoscopic ultrasound-guided ablation and sensing is included having an ultrasound endoscope that can include an ultrasound transducer and a radiofrequency catheter configured to be disposed within the ultrasound endoscope. The radiofrequency catheter can include a first electrode pair disposed on the radiofrequency catheter, where the first electrode pair configured to be placed at or near at a site of a celiac plexus. The system is configured to sense a baseline electrical property to verify placement of the first electrode pair at the celiac plexus; deliver a radiofrequency energy to the celiac plexus through the first electrode pair; and sense a post-treatment electrical property of the celiac plexus to verify neurolysis of the celiac plexus. Other embodiments are also included herein.

In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

Embodiments described herein relate to methods, systems, and devices that are used in the radio frequency ablation of tissues in a medical treatment. Probe tips may include an expandable balloon or basket with an active RF treatment area localized on a particular portion of the expandable balloon or basket. The broad or localized active treatment region on the balloon or basket allows a medical practitioner to more completely provide treatment to a region of target tissue, a volume within a tissue such as a bone, or a surface of a tissue such as a bone. Probe tips may also use magnetic materials which reduce the risk of injuring surrounding tissues adjacent to tissues under treatment.

An annular mapping catheter includes a catheter body. The catheter body has a distal end and a proximal end. The distal end of the catheter body is provided with a distal end assembly, and the proximal end of the catheter body is provided with a handle. The distal end assembly is made of a head end catheter that has a shape memory function. The distal end assembly in a free state presents a predetermined bent shape including an annular part and a vertical part. The vertical part connects the annular part to the catheter body. The distal end assembly is provided with an electrode. The annular mapping catheter can detect an electrocardiogram activity near a pulmonary vein ostium and can better locate a cryoballoon in the heart.

An electrosurgical handpiece is provided that includes a squeezable handle. The squeezable handle has a back grip and a finger grip that can be squeezed to actuate electrosurgical handpiece. The back grip and the finger grip are connected by a lower malleable region that has an elasticity greater than the remainder of the squeezable handle.

A catheter with basket-shaped electrode assembly with spines configured for hyper-flexing in a predetermined, predictable manner when a compressive force acts on the assembly from either its distal end or its proximal end. At least one spine has at least one region of greater (or hyper) flexibility that allows the electrode assembly to deform, for example, compress, for absorbing and dampening excessive force that may otherwise cause damage or injury to tissue wall in contact with the assembly, without compromising the structure and stiffness of the remaining regions of the spine, including its distal and proximal regions. The one or more regions of greater flexibility in the spine allow the spine to flex into a generally V-shape configuration or a generally U-shape configuration.

An injectable electrode which is manufactured in the body by curing from a liquid phase to a solid phase, and therefore molding to the contours of the bodily structures where it is injected.

A medical introducer is provided for use in locating an energy delivery probe, such as an RF ablation probe, at a target location in tissue. The introducer includes a proximal hub and an elongate cannula having a distal end and a proximal end, the proximal end connected to the hub. The cannula is formed entirely of an electrically insulating polymer material and includes a tapered distal tip. An RF ablation probe system is also provided that includes an RF ablation probe assembly, a stylet, and the introducer.

A device having an optical element with a conductive coating. The device may include an optical element, a conductive material and at least one connector. The conductive material is disposed on at least a portion of the optical element. The optical element, for example, may be an object lens of an endoscope or an optical coupler. The connectors (acting as terminal(s)) are capable of providing energy (such as electrical energy) to the conductive material. In one aspect, the conductive material is an optically transparent material. Advantageously, the device may allow visualization of an objectsuch as body tissue or other matterconcurrent with the application of energy to the object via the conductive coating. This allows the user to observe the alteration of tissue and other matter in real time as the energy is delivered.

A hand piece for handling an optical fiber during a laser-surgical intervention comprises a handle body elongated along a main axis and having a through hole extending along the main axis. A guide tube having a tube lumen aligned and communicating with the through hole is attached to the handle body. A fixing device is provided in the handle body for fixing the optical fiber extending through the through hole and the tube lumen in direction of the main axis. The guide tube is made of a shaped memory alloy, which has a transition temperature between 50 C. and 120 C., and which has a straight base shape. Below the transition temperature, the guide tube is bendable by plastic deformation out of the straight base shape into a curved shape, and, when heated up above the transition temperature, the guide tube returns to its straight base shape.