Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A.sub.1 is selected from: C(O)NR.sup.8, S(O).sub.2NR.sup.8, S(O)NR.sup.8, and R.sup.7NR.sup.8; A.sub.2 is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C.sub.1-6 alkyl; R.sup.1, R.sup.2, R.sup.5, and R.sup.6 may be the same or different and are selected from: hydrogen, substituted or unsubstituted C.sub.1-C.sub.5 alkyl or heteroalkyl; n is an integer from 0 to 20,000; R.sup.3 and R.sup.4 are independently selected from: hydrogen, X, substituted or unsubstituted C.sub.1-6 alkyl; X is selected from: F, Cl, Br and I; R.sup.7 is selected from: substituted or unsubstituted C.sub.1-C.sub.6 alkyl; and R.sup.8 is selected from: hydrogen, substituted or unsubstituted C.sub.1-C.sub.6 alkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

##STR00001##

The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A.sub.1 is selected from: C(O)NR.sup.8, S(O).sub.2NR.sup.8, S(O)NR.sup.8, and R.sup.7NR.sup.8; A.sub.2 is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C.sub.1-6 alkyl; R.sup.1, R.sup.2, R.sup.5, and R.sup.6 may be the same or different and are selected from: hydrogen, substituted or unsubstituted C.sub.1-C.sub.5 alkyl or heteroalkyl; n is an integer from 0 to 20,000; R.sup.3 and R.sup.4 are independently selected from: hydrogen, X, substituted or unsubstituted C.sub.1-6 alkyl; X is selected from: F, Cl, Br and I; R.sup.7 is selected from: substituted or unsubstituted C.sub.1-C.sub.6 alkyl; and R.sup.8 is selected from: hydrogen, substituted or unsubstituted C.sub.1-C.sub.6 alkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

##STR00001##

The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.

The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.

Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.

Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.

The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.