A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.

Isothiocyanatoethynylbenzene derivatives of formula I

##STR00001##

liquid crystal media comprising the isothiocyanatoethynylbenzene derivatives, and high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas (e.g., phased array antennas), and devices comprising said components. Further, an optical component comprising said liquid-crystalline media, operable in the infrared region of the electromagnetic spectrum, the use of said LC medium in the infrared (IR) region, and devices comprising said optical component.

Isothiocyanatoethynylbenzene derivatives of formula I

##STR00001##

liquid crystal media comprising the isothiocyanatoethynylbenzene derivatives, and high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas (e.g., phased array antennas), and devices comprising said components. Further, an optical component comprising said liquid-crystalline media, operable in the infrared region of the electromagnetic spectrum, the use of said LC medium in the infrared (IR) region, and devices comprising said optical component.

Isothiocyanatoethynylbenzene derivatives of formula I ##STR00001##
liquid crystal media comprising the isothiocyanatoethynylbenzene derivatives, and high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas (e.g., phased array antennas), and devices comprising said components. Further, an optical component comprising said liquid-crystalline media, operable in the infrared region of the electromagnetic spectrum, the use of said LC medium in the infrared (IR) region, and devices comprising said optical component.

Isothiocyanatoethynylbenzene derivatives of formula I ##STR00001##
liquid crystal media comprising the isothiocyanatoethynylbenzene derivatives, and high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas (e.g., phased array antennas), and devices comprising said components. Further, an optical component comprising said liquid-crystalline media, operable in the infrared region of the electromagnetic spectrum, the use of said LC medium in the infrared (IR) region, and devices comprising said optical component.