Systems and methods are configured to detect and/or ablate cancerous tissue, such as during surgery. The system uses Laser Ramen Spectroscopy (LRS) or Surface Enhanced Raman Spectroscopy (SERS) to enhance a detection signal pursuant to a spectroscopy analysis of tissue. Rapid in situ detection of cancer can be combined with immediate laser thermal ablation of the cancerous tissue. The detection and ablation can occur before, during, or after surgical resection.

Described are compositions comprising nucleic acids encoding CD3-half-BiTE, CXCL9, CTLA-4 scFv, and IL-12for use in treating cancer. Methods of analyzing CXCR3 expression in a tumor to identify subjects likely to respond to the compositions are also described.

Described is a medical instrument (1) for the minimally invasive removal of biological material from a human or animal body with a hollow needle (2), which, at a distal end (4) delimiting an interior (3) of the hollow needle (2), includes a peripheral edge (5) having a cutting edge, at least in sections, and with a cutting wire (6), which is arranged such that the cutting wire (6) can be moved relative to the hollow needle (2) at least partially outside the interior (3).

The technical solution described is characterized in that, in the interior (3) of the hollow needle (2), a guide element (7), slidable in the longitudinal direction of the hollow needle (2), is provided, at which the cutting wire (6) is fastened at least at one point and that a means of movement (8) for moving the cutting wire (6) is provided, through which a length of a part of the cutting wire (6) located outside the interior (3) can be changed in a targeted manner as a function of the actuation of a control element (11) acting on the means of movement (8).

Provided herein are methods for inducing an anti-tumor immune response and/or treating cancer comprising treating tumor tissue of the subject with energy to induce fractional tissue damage in combination with one or more checkpoint molecule modulating agents.

Systems and methods for pumping milk from a breast responsive to a controller, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Systems and methods for pumping milk from a breast responsive to a controller, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

The present disclosure provides a medical device (100) for inducing cell death in cancer cells. The device comprises a signal generator (102) arranged to generate a pulsed electrical signal, and a transmitter (116) arranged to receive the pulsed electrical signal and generate, in response to the electrical signal, an electric field in a treatment volume. The device (100) is arranged such that the pulsed electrical signal received by the transmitter (116) has a pulse width of 0.1 microsecond to 1 millisecond, and a signal frequency of 10 Megahertz to 20 Gigahertz. The present disclosure also provides a method of inducing cell death. The method comprising a step of generating, using a transmitter (116), a pulsed time varying electric field in a treatment volume comprising a volume of cells to be treated. The electric field has a pulse width of 0.1 microsecond to 1 millisecond, and a signal frequency of 10 Megahertz to 20 Gigahertz.

Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.

The present disclosure is directed to systems, device and methods for cancer ablation treatment of human and animal subjects through the application of a combination of electromagnetic sources, in particular, microwave and radio frequency radiation that are focused on a tumor harboring magnetic or other metallic nanoparticles to result in synergetic heating effect whereby the tumor is heated to ablative temperature due to the strong absorption of the nanoparticles while the surrounding healthy tissue is hardly affected.

Provided are methods for anesthetizing a human patient undergoing surgery, and/or pain block procedures. In some forms, the methods include inserting at least one cryo-needle into a target region of the patient, the target region including a site superficial to a target intercostal nerve and cooling the cryo-needle to inhibit the target intercostal nerve.