Electrosurgical systems and methods are provided for RF nerve ablation, wherein a control console has multiple RF amplifiers associated with multiple channels, and multiple DC power supplies each dedicated to a corresponding one of the RF amplifiers. Each of a plurality of power supply relays are coupled between one of the DC power supplies and the dedicated corresponding one of the RF amplifiers. A controller is configured to apply switching signals to control each of the power supply relays to selectively switch on and off connections between the DC power supplies and the dedicated corresponding RF amplifiers. The controller may apply control signals to each RF amplifier sequentially, one at a time, to deliver energy separately and independently to each of the corresponding channels. The controller may be configured to apply the switching signals to self-grounding relays to selectively switch on and off connections between the channels and return relays.

A catheter system for ablation of tissue around a blood vessel, e.g., the pulmonary artery, to reduce neural activity of nerves surrounding the blood vessel. The catheter system includes an elongate shaft having a proximal portion coupled to a handle, and a distal portion. The distal portion includes a transducer and an expandable anchor, which may be actuated to transition between a collapsed delivery state and an expanded deployed state where the anchor centralizes the transducer within the blood vessel. The transducer may be actuated to emit energy to reduce neural activity of the nerves surrounding the blood vessel. Systems and method are further provided for confirming that neural activity of the nerves surround the blood vessel has been sufficiently reduced.

The invention provides systems and methods providing precision targeting of neural structures for the treatment of a condition while avoiding collateral damage to surrounding structures, such as blood vessels and/or other nerve tissue. The invention further provides systems and methods for treating at least one of rhinitis, congestion, and/or rhinorrhea via thrombus formation. The invention further provides systems and methods for detection, identification, and precision targeting of neural tissue for the treatment of a neurological condition while minimizing or avoiding collateral damage to surrounding or adjacent non-neural tissue, such as blood vessels and bone, as well as non-targeted neural tissue.

Described herein is a method of treating migraines using PFA ablation technology which includes advancing a pulse field ablation delivery member into a nasal cavity (both unilateral and bilateral) of a patient with the pulse field ablation member in a first collapsed configuration and contacting a surface of a nasal cavity tissue with the pulse field ablation delivery member without penetrating or piercing the nasal cavity tissue surface. The treatment further includes reconfiguring the pulse field ablation delivery member from the first collapsed configuration to an expanded configuration after introducing the pulse field ablation member into the desired position within the nasal cavity, and ablating a target treatment site with the pulse field ablation delivery member in order to treat or prevent at least one of the group of medical conditions, wherein the target treatment site includes at least one nasal nerve tissue or nasal blood vessel with or without contact.

This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.

Electrosurgical systems and methods are provided for RF nerve ablation, wherein a control console is utilized with a passive or active cable accessory connecting to different of electrode attachments, such as monopolar and bipolar self-grounding types. The control console has multiple RF amplifiers that are associated with multiple channels of the control console and that are energized according to control signals non-simultaneously applied by a controller of the control console. The control console stores and processes identification data and usage data relating to cable accessories and electrode attachments that are connected or have been connected to the control console over time. The control console displays a representation of this processed data on a graphical user interface. The control console further provides components and techniques for implementing stimulation and impedance verification/calibration for situations where the stimulation signals or impedance measurement signals are provided by the control console.

Method for ameliorating secondary pulmonary hypertension in a patient including determining a pulmonary vascular resistance (PVR) of the patient suffering from secondary pulmonary hypertension; assessing a change in the PVR in response to a selection treatment; and treating the patient with a pulmonary artery manipulation device to provide pulmonary artery denervation if the patient is determined to suffer from fixed PH, thereby ameliorating the secondary pulmonary hypertension of the patient.

The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

In certain embodiments, the present disclosure provides an anthropomorphic phantom for use with cryoneurolysis training. The anthropomorphic phantom having a body shaped to simulate a human anatomical structure. In some forms, the phantom body comprises a first material configured to simulate human soft tissue, a simulated nerve embedded within the first material, and a simulated fascial plane embedded within the first material superficial to the simulated nerve.

Ablation systems and methods detect and address distortion caused by a variety of factors. A method includes measuring a temperature curve at target tissue; applying ablation energy to the target tissue; determining a peak temperature on the temperature curve; if the peak temperature is greater than the predetermined peak temperature, determining a time at which the temperature curve crosses to a lower temperature; and if the determined time is greater than a predetermined time, generating a message indicating that the target tissue was successfully ablated. Another method includes determining a distance between a remote temperature probe and an ablation probe, applying ablation energy to target tissue, measuring temperature at the remote temperature probe, estimating ablation size based on the determined distance and the temperature measured by the remote temperature probe, and determining whether the target tissue is successfully ablated based on the estimated ablation size.