The invention relates to primary para-phenylenediamine compounds substituted with an aliphatic chain comprising a cationic heterocyclic group according to formula (I), as well as the organic or mineral acid or base addition salts thereof, optical isomers, geometric isomers, tautomers, mesomers and/or solvates thereof, such as hydrates. Formula (I), wherein: ALK is a linear or branched, optionally substituted, alkylene chain comprising 3 to 8 carbon atoms; HET.sup.+ is a saturated or unsaturated, aromatic or non-aromatic cationic heterocyclic group, optionally substituted, comprising 5 to 0 links, optionally substituted, and comprising one or more ammonium groups; and An.sup.−, present or absent, is a mineral or organic anionic counterion ensuring the electroneutrality of the molecule. The present invention also relates to a composition comprising one or more of these previously defined compounds, in a medium suitable for dyeing. The present invention lastly relates to a dyeing device consisting of a first compartment which contains said composition, and a second compartment containing one or more oxidising agents.

##STR00001##

Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I):

##STR00001##

or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein n, x, A, Q.sub.1, Q.sub.2, Z, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

The present disclosure generally provides conjugates diynes, particularly 6,8-diyne amides, and the use of such compounds and related compounds as flavor modifiers. In some aspects, the disclosure provides compositions that include such conjugated diynes, such as compositions that include such conjugated diynes and one or more additional compounds, such as a sweetener, salt, a glutamate, an arginate, and the like. In some other aspects, the disclosure provides methods of reducing or eliminating the amount of sweetener, salt, glutamate, or arginate in a food or beverage product.

The present disclosure generally provides conjugates diynes, particularly 6,8-diyne amides, and the use of such compounds and related compounds as flavor modifiers. In some aspects, the disclosure provides compositions that include such conjugated diynes, such as compositions that include such conjugated diynes and one or more additional compounds, such as a sweetener, salt, a glutamate, an arginate, and the like. In some other aspects, the disclosure provides methods of reducing or eliminating the amount of sweetener, salt, glutamate, or arginate in a food or beverage product.

The present invention relates to adducts between sp.sup.2 hybridized carbon allotropes and pyrrole derivatives comprising at least one sulphur atom, and crosslinkable elastomer compositions comprising such adducts. The present invention further relates to tyres for vehicle wheels comprising at least one structural element comprising a crosslinked elastomer material obtained by crosslinking of such crosslinkable elastomer compositions.

The present invention relates to adducts between sp.sup.2 hybridized carbon allotropes and pyrrole derivatives comprising at least one sulphur atom, and crosslinkable elastomer compositions comprising such adducts. The present invention further relates to tyres for vehicle wheels comprising at least one structural element comprising a crosslinked elastomer material obtained by crosslinking of such crosslinkable elastomer compositions.

Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp.sup.2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an inorganic oxide-hy-droxide. A process for preparing said adducts is also described.

Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

A light-emitting device with high emission efficiency is provided. The light-emitting device includes a fluorescent substance and a phosphorescent substance or a thermally activated delayed fluorescent material; the fluorescent substance includes a luminophore and five or more protecting groups; the luminophore is a condensed aromatic ring or a condensed heteroaromatic ring; the five or more protecting groups each have any one of an alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted cycloalkyl group having 3 to 10 carbon atoms, and a trialkylsilyl group having 3 to 12 carbon atoms; the lowest singlet excitation energy level of the fluorescent substance is higher than the lowest triplet excitation energy level of the phosphorescent substance or the thermally activated delayed fluorescent material; and light emission can be obtained from both the phosphorescent substance and the phosphorescent substance or the thermally activated delayed fluorescent material.