Provided are a compound having an effect on preventing photolysis of a liquid crystal composition, and high solubility in the liquid crystal composition, a liquid crystal composition containing the compound and a liquid crystal display device including the composition.

A compound is represented by formula (1), a liquid crystal composition contains the compound and a liquid crystal display device uses the composition.

##STR00001##

In formula (1), for example, R1 is alkyl having 1 to 10 carbons; R2 is hydrogen, hydroxy, oxy radical or alkyl; ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-phenylene or pyridine-2,5-diyl; Z1 and Z2 are independently a single bond or alkylene; and a and b are independently 0 or 1.

Provided are a compound having an effect on preventing photolysis of a liquid crystal composition, and high solubility in the liquid crystal composition, a liquid crystal composition containing the compound and a liquid crystal display device including the composition.

A compound is represented by formula (1), a liquid crystal composition contains the compound and a liquid crystal display device uses the composition.

##STR00001##

In formula (1), for example, R1 is alkyl having 1 to 10 carbons; R2 is hydrogen, hydroxy, oxy radical or alkyl; ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-phenylene or pyridine-2,5-diyl; Z1 and Z2 are independently a single bond or alkylene; and a and b are independently 0 or 1.

The present invention concerns a compound of general formula (I): ##STR00001##
in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.

The present invention concerns a compound of general formula (I): ##STR00001##
in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.

The present invention relates to inhibitors of 11- hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11- hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

The present invention relates to inhibitors of 11- hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11- hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

The present invention relates to a coumarin derivative of Formula (L) for detection of cysteine and process for preparation thereof. The present invention further relates to a process of detection of cysteine residues present in protein as well as the cysteine released by the enzymatic action of aminoacylase 1 by using coumarin derivative of Formula (L).

##STR00001##

The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate has a very good crystal form and is well suitable for recrystallization purification; further, the effect of impurity removal effect is very good, and any single impurity can be controlled less than 0.1%.

The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate has a very good crystal form and is well suitable for recrystallization purification; further, the effect of impurity removal effect is very good, and any single impurity can be controlled less than 0.1%.

The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.