Patent classifications
C07D211/54
SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
The present application relates to a sulfur-containing isoindoline derivative, and a preparation method therefor and medical use thereof. In particular, the present disclosure relates to a sulfur-containing isoindoline derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, particularly use thereof as a Cereblon modulator in the field of treatment of multiple myeloma.
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NOVEL AMINO ACID DERIVATIVES
- Naoki OKADA ,
- Kyosuke UEDA ,
- Masatoshi TAKUWA ,
- Shunichi NAKANO ,
- Kotaro TOKUMOTO ,
- Tomoko ASHIZAWA ,
- Shuhei YAMAKOSHI ,
- Yutaka KOBAYASHI ,
- Katsuma MATSUI ,
- Ayumu MATSUDA ,
- Masatoshi MATSUMOTO ,
- Keiichi MASUYA ,
- Atsushi YOSHIZAWA ,
- Masahiko KINEBUCHI ,
- Takeru EHARA ,
- Masami YAMADA ,
- Kouki MORIMOTO ,
- Yoshihide MIZUKOSHI ,
- Haruaki KURASAKI ,
- Motoki MURAI ,
- Kentarou FUKUMOTO ,
- Douglas Robert CARY
A novel amino acid derivative is provided, wherein the amino acid derivative is expected to improve solubility of polypeptides comprising the derivative therein.
Nitrogen-containing compound, electronic component using same and electronic device
The present disclosure belongs to the field of organic electroluminescent materials, and specifically relates to a nitrogen-containing compound, an electronic component using the nitrogen-containing compound and an electronic device using the nitrogen-containing compound. The nitrogen-containing compound has a structure as shown in Formula 1. When the nitrogen-containing compound of the present disclosure is used in an organic electroluminescent device, properties of the device can be effectively improved. ##STR00001##
Nitrogen-containing compound, electronic component using same and electronic device
The present disclosure belongs to the field of organic electroluminescent materials, and specifically relates to a nitrogen-containing compound, an electronic component using the nitrogen-containing compound and an electronic device using the nitrogen-containing compound. The nitrogen-containing compound has a structure as shown in Formula 1. When the nitrogen-containing compound of the present disclosure is used in an organic electroluminescent device, properties of the device can be effectively improved. ##STR00001##
NITROGEN-CONTAINING COMPOUND, AND ELECTRONIC ELEMENT AND ELECTRONIC APPARATUS USING SAME
The present disclosure belongs to the technical field of organic materials, and specifically disclosed are a nitrogen-containing compound, and an electronic element and electronic apparatus using the same, the nitrogen-containing compound having a structure represented by a formula F-1. When the compound of the present disclosure is used as an electron blocking layer for manufacturing an organic electroluminescent device, the service life of the organic electroluminescent device may be effectively prolonged, and the luminous efficiency or driving voltage may be improved to a certain extent.
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NITROGEN-CONTAINING COMPOUND, AND ELECTRONIC ELEMENT AND ELECTRONIC APPARATUS USING SAME
The present disclosure belongs to the technical field of organic materials, and specifically disclosed are a nitrogen-containing compound, and an electronic element and electronic apparatus using the same, the nitrogen-containing compound having a structure represented by a formula F-1. When the compound of the present disclosure is used as an electron blocking layer for manufacturing an organic electroluminescent device, the service life of the organic electroluminescent device may be effectively prolonged, and the luminous efficiency or driving voltage may be improved to a certain extent.
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COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE
A compound represented by a formula (1) and having at least one deuterium atom is provided. In the formula (1), n is 1 to 4, L.sub.1 is a divalent group or a group represented by a formula (11) and R.sub.111 to R.sub.119 and R.sub.211 to R.sub.219 are each independently a hydrogen atom or a substituent, where the compound represented by the formula (1) does not include a group represented by —N(R.sub.906) (R.sub.907) and R.sub.906 and R.sub.907 are each independently a hydrogen atom, an alkyl group having 1 to 50 carbon atoms, or the like. In the formula (11), X.sub.13 is an oxygen atom or a sulfur atom, Y.sub.1 to Y.sub.8 are each independently CR.sub.300 or a nitrogen atom, and two of R.sub.300 are a single bond bonded with *a or other L.sub.1 and a single bond bonded with *b or other L.sub.1.
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COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE
A compound represented by a formula (1) and having at least one deuterium atom is provided. In the formula (1), n is 1 to 4, L.sub.1 is a divalent group or a group represented by a formula (11) and R.sub.111 to R.sub.119 and R.sub.211 to R.sub.219 are each independently a hydrogen atom or a substituent, where the compound represented by the formula (1) does not include a group represented by —N(R.sub.906) (R.sub.907) and R.sub.906 and R.sub.907 are each independently a hydrogen atom, an alkyl group having 1 to 50 carbon atoms, or the like. In the formula (11), X.sub.13 is an oxygen atom or a sulfur atom, Y.sub.1 to Y.sub.8 are each independently CR.sub.300 or a nitrogen atom, and two of R.sub.300 are a single bond bonded with *a or other L.sub.1 and a single bond bonded with *b or other L.sub.1.
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Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
Disclosed are compounds of general formulas I-III that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. ##STR00001##
Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
Disclosed are compounds of general formulas I-III that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. ##STR00001##