Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

An electrosurgical device (10) is provided that is operable to deliver microwave energy within a controlled angular expanse to cause targeted tissue ablation. The device (10) comprises a blocking or reflecting material such as cylindrical members (34) that are laterally spaced from the antenna (20) that is operable to emit the microwave energy. The reflecting material creates regions in and/or surrounding the device into which sensors (51), such as thermocouple wires, may be placed to monitor a condition associated with the device or the patient's body.

Systems and methods for protecting non-target tissue from damage during a medical procedure for disrupting target tissue via heat application are disclosed. Data associated with the target tissue to be disrupted may be received. Based on the received data, one or more non-target objects of tissue that may be affected by the applied heat are identified. Both a temperature threshold and thermal dose threshold for each of the one or more non-target objects may be generated. Both the temperature and the thermal dose of each of the one or more non-target objects may be evaluated during performance of the medical procedure. A response may be generated when either the evaluated temperature of any of the one or more non-targe objects reaches the corresponding temperature threshold or the thermal dose of any of the one or more non-target objects reaches the corresponding thermal dose threshold.

The disclosure provides a method of manufacturing a flexible circuit electrode assembly and an apparatus manufactured by said method. According to the method, an electrically conductive sheet is laminated to an electrically insulative sheet. An electrode is formed on the electrically conductive sheet. An electrically insulative layer is formed on a tissue contacting surface of the electrode. The individual electrodes are separated from the laminated electrically insulative sheet and the electrically conductive sheet. In another method, a flexible circuit is vacuum formed to create a desired profile. The vacuum formed flexible circuit is trimmed. The trimmed vacuum formed flexible circuit is attached to a jaw member of a clamp jaw assembly.

Devices and systems used to ablate tissue of a tumor using laser energy are disclosed. The devices and systems include a laser probe and a magnetic resonance (MR) safe temperature probe. The MR safe temperature probe includes an optical sensor. A bone anchor fixture separates the laser probe and the MR safe temperature probe to prevent interference in the MR safe temperature probe data. Proton Resonance Frequency (PRF) thermometry is used to model a temperature of a pixel of an MR image located adjacent the optical sensor. The modeled pixel temperature and the measured temperature are compared and monitored. Exceeding a threshold difference value causes an intervening action to occur.

A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.

An electrosurgical device having a radiating tip portion for delivering electromagnetic energy to biological tissue, where the electrosurgical device is disposed in a catheter. The electrosurgical device is movable relative to the catheter between a deployed position where the radiating tip portion is exposed and a retracted position where the radiating tip portion is contained within the catheter. In this manner, the radiating tip portion may be retracted until the moment when it is to be used. This may facilitate insertion of the device through an instrument channel of a surgical scoping device. In particular, this may prevent the radiating tip portion from catching on the instrument channel when the device is inserted into the instrument channel, which could cause damage to the instrument channel and/or radiating tip portion.

A treatment method and a treatment system capable of effectively irradiating an antibody-photosensitive substance bound to a tumor cell with a near-infrared ray. The treatment method includes: intravenously administering the antibody-photosensitive substance; inserting a guide wire and a catheter into a main artery of an organ having the tumor cell; removing the guide wire; inserting an optical fiber into the catheter and advancing the optical fiber to a target position while checking a position of the optical fiber with an orientation marker disposed on the optical fiber; and irradiating the antibody-photosensitive substance bound to a tumor cell membrane with the near-infrared ray from the optical fiber while reducing an influence of blood in the artery on the near-infrared ray after 12 hours to 36 hours from intravenous administration.

An ultrasound exposure safety processor is configured for spatially relating respective definitions of an imaging zone, and an extended dead-tissue zone that includes both a dead-tissue zone and a surrounding margin. Based on whether a push pulse focus is to be within the extended dead-tissue zone, the processor automatically decides a level of acoustic power with which the pulse is to be produced. If the pulse focus is to be within the extended dead-tissue zone, the pulse may be produced with a mechanical index (MI), a thermal index (TI), and/or a spatial-peak-temporal-average intensity (IspTA) that exceeds respectively 1.9, 6.0 and 720 milliwatts per square centimeter. The imaging zone may be definable interactively to dynamically trigger the deciding and the producing, with push pulse settings being dynamically derived automatically. A display of multiple push pulse sites allows user manipulation of spatial definition indicia to dynamically control displacement tracking.

A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly. The delivery assembly further includes a sled assembly removably coupled to the console at the vial containment region and a safety shield removably coupled to the console over the vial containment region such that the vial engagement mechanism and the sled assembly are encapsulated within the safety shield when the safety shield is coupled thereto. The sled assembly, the vial assembly, and the safety shield are configured to inhibit radioactive emissions from within the vial containment region.