A method of synthesizing a reaction product of the formula R.sub.3-R.sub.4 by reacting a pnictogenium salt of the formula ##STR00001##
including a phosphonium salt of the formula ##STR00002##
with a Lewis acid in the presence of a nucleophile. The reaction products can then be isolated for use. R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, aralkyl, alkoxy, amino, and organosilyl. R.sub.3 and R.sub.4 are individually selected from the group consisting of optionally substituted monocyclic or polycyclic heteroaromatic moieties, optionally substituted monocyclic or polycyclic heteroaliphatic moieties, and optionally substituted linear or branched heteroaliphatic moieties. R.sub.1 or R.sub.2 optionally forms a covalent bond with R.sub.3 or R.sub.4. X is an anion.

A method of synthesizing a reaction product of the formula R.sub.3-R.sub.4 by reacting a pnictogenium salt of the formula ##STR00001##
including a phosphonium salt of the formula ##STR00002##
with a Lewis acid in the presence of a nucleophile. The reaction products can then be isolated for use. R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, aralkyl, alkoxy, amino, and organosilyl. R.sub.3 and R.sub.4 are individually selected from the group consisting of optionally substituted monocyclic or polycyclic heteroaromatic moieties, optionally substituted monocyclic or polycyclic heteroaliphatic moieties, and optionally substituted linear or branched heteroaliphatic moieties. R.sub.1 or R.sub.2 optionally forms a covalent bond with R.sub.3 or R.sub.4. X is an anion.

The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.

##STR00001##

The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.

##STR00001##

The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification. ##STR00001##

The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification. ##STR00001##

The invention pertains to a fluoroelastomer composition comprising a vinylidene-fluoride based fluoroelastomer, a polyhydroxylated compound, a basic compound, a pyridinium-type salt having an aromatic ring-quaternized nitrogen atom, and comprising at least two groups having a central carbon atom which bears acidic hydrogen atoms; and an accelerant, which possesses an improved molding behaviour, leading to shaped parts possessing less blisters and surface defects.

The invention pertains to a fluoroelastomer composition comprising a vinylidene-fluoride based fluoroelastomer, a polyhydroxylated compound, a basic compound, a pyridinium-type salt having an aromatic ring-quaternized nitrogen atom, and comprising at least two groups having a central carbon atom which bears acidic hydrogen atoms; and an accelerant, which possesses an improved molding behaviour, leading to shaped parts possessing less blisters and surface defects.

In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identical groups. Also provided herein are compositions for use in the preparation of the secondary amine.

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein A, LG, n and m are as defined in the Summary of the Invention.

##STR00001##