A method of preparing benzyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate (I) from benzyl 4,5-difluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate (II) is described. The method includes the use of amination and chlorination process steps to provide the compound of Formula I.

Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.

Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.

The present invention relates to the field of fine chemical industry. Specifically disclosed are a method for synthesizing 2-methylpyridine from aniline, and a method for selectively and continuously producing 2-methylpyridine and diphenylamine from aniline. The method comprises: in a hydrogen-containing atmosphere, enabling aniline and a catalyst to undergo a contact reaction at a temperature of 100-400 C., wherein the catalyst is zeolite carrying a metal component, and the metal component comprises an active metal component selected from at least one of W, Mo, Ni, and Co; controlling the temperature of the contact reaction to be 100-240 C. to obtain a product mainly consisting of 2-methylpyridine; and controlling the temperature of the contact reaction to be 260-400 C. to obtain a product mainly consisting of diphenylamine.

The present invention relates to the field of fine chemical industry. Specifically disclosed are a method for synthesizing 2-methylpyridine from aniline, and a method for selectively and continuously producing 2-methylpyridine and diphenylamine from aniline. The method comprises: in a hydrogen-containing atmosphere, enabling aniline and a catalyst to undergo a contact reaction at a temperature of 100-400 C., wherein the catalyst is zeolite carrying a metal component, and the metal component comprises an active metal component selected from at least one of W, Mo, Ni, and Co; controlling the temperature of the contact reaction to be 100-240 C. to obtain a product mainly consisting of 2-methylpyridine; and controlling the temperature of the contact reaction to be 260-400 C. to obtain a product mainly consisting of diphenylamine.

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs.sub.2CO.sub.3 or CsHCO.sub.3.

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs.sub.2CO.sub.3 or CsHCO.sub.3.

In one aspect, there is provided a method of coupling a first aromatic compound having a fluorosulfonate substituent to a second aromatic compound having a boron-containing substituent. In another aspect, there is provided a method of coupling a first aromatic compound having a hydroxyl substituent to a second aromatic compound having a boron-containing substituent in a one-pot reaction.

##STR00001##

The invention relates to a method for oxidative electrochemical amination of non-activated or deactivated aromatic systems by means of boron-doped diamond anodes, and in particular to the production of 1,5-diaminonaphthalene and 1-amino-5-nitronaphthalene according to said method.