Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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213/00
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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C07D213/02
having three double bonds between ring members or between ring members and non-ring members
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C07D213/04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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C07D213/24
with substituted hydrocarbon radicals attached to ring carbon atoms
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C07D213/54
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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C07D213/54

NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
20190270721 · 2019-09-05 ·

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

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MODULATORS OF THE INTEGRATED STRESS PATHWAY
20190135772 · 2019-05-09 ·

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

POLYMORPHIC FORM OF N-{6-(2-HYDROXYPROPAN-2-YL)-2-[2-(METHYLSULPHONYL)ETHYL]-2H-INDAZOL-5-YL}-6-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE
20190112270 · 2019-04-18 · ·

The present invention relates to crystalline forms of N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide, to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the control of disorders.

SYNTHESIS OF INDAZOLES
20190106407 · 2019-04-11 · ·

The present invention relates to a novel method of preparing a 2-substituted indazole of structure: (I), to intermediate compounds, and to the use of intermediate compounds for the preparation of said 2-substituted indazole.

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SYNTHESIS OF INDAZOLES
20190106407 · 2019-04-11 · ·

The present invention relates to a novel method of preparing a 2-substituted indazole of structure: (I), to intermediate compounds, and to the use of intermediate compounds for the preparation of said 2-substituted indazole.

##STR00001##

NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
20180291000 · 2018-10-11 ·

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

##STR00001##

NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
20180291000 · 2018-10-11 ·

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

##STR00001##

MODULATORS OF THE INTEGRATED STRESS PATHWAY
20240307382 · 2024-09-19 ·

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

OXIMES AND THEIR USE IN TREATMENT OF GBA-RELATED DISEASES
20240383853 · 2024-11-21 ·

The present invention relates to oximes, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

OXIMES AND THEIR USE IN TREATMENT OF GBA-RELATED DISEASES
20240383853 · 2024-11-21 ·

The present invention relates to oximes, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.