Patent classifications
C07D213/78
4-amino-6-(halo-substituted-alkyl)-picolinates and their use as herbicides
Provided herein are 4-amino-6-(halo-substituted-alkyl)-picolinic acids and their derivatives, compositions comprising the acids and their derivatives, and methods of use thereof as herbicides.
Process for making reverse transcriptase inhibitors
The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
Process for making reverse transcriptase inhibitors
The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I)
##STR00001## in which X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.1, R.sup.2, R.sup.3, n have the meanings given in the descriptionto their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation
N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I)
##STR00001## in which X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.1, R.sup.2, R.sup.3, n have the meanings given in the descriptionto their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation
Inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001##
wherein n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y, Z and ##STR00002##
have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001##
wherein n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y, Z and ##STR00002##
have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Amino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001##
wherein n, m, t, R.sup.1, R.sup.2, L, Q, X, Y, Z and ##STR00002##
have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Amino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001##
wherein n, m, t, R.sup.1, R.sup.2, L, Q, X, Y, Z and ##STR00002##
have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
COMPOSITIONS FOR AND METHODS OF MODULATING RNA STABILITY
Disclosed herein are DMZ-derived compositions for and methods of modulating the expression and/or function of disease associated and/or diseasing causing secondary RNA structures and tertiary RNA structures.