Patent classifications
C07D215/42
Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof
The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses thereof. Formula (I). ##STR00001##
Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof
The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses thereof. Formula (I). ##STR00001##
BISAMINOQUINOLINES AND BISAMINOACRIDINES COMPOUNDS AND METHODS OF THEIR USE
The disclosure is directed to bisaminoquinolines and bisaminoacridines as autophagy inhibitors for treating cancer and other disease states and conditions.
BISAMINOQUINOLINES AND BISAMINOACRIDINES COMPOUNDS AND METHODS OF THEIR USE
The disclosure is directed to bisaminoquinolines and bisaminoacridines as autophagy inhibitors for treating cancer and other disease states and conditions.
NOVEL CDK 8/19 INHIBITORS
- Aleksei Leonidovich MINDICH ,
- Svetlana Leonidovna GORBUNOVA ,
- Aleksandra Vladimirovna POPKOVA ,
- Artsiom Evgenievich SHEKHAUTSOU ,
- Andrei Ivanovich ALAFINOV ,
- Mariia Andreevna KASATKINA ,
- Natalia Vladimirovna KOZHEMYAKINA ,
- Anna Sergeevna KUSHAKOVA ,
- Elena Aleksandrovna MAKSIMENKO ,
- Leonid Evgen`evich MIKHAYLOV ,
- Mariia Sergeevna MISHINA ,
- Anna Jur'evna CHESTNOVA ,
- Dmitry Valentinovich Morozov
The present invention relates to novel compounds of formula (1), which have the properties of a CDK8/19 inhibitor, and to a pharmaceutical composition containing said compounds, and to the use of said compounds and composition as pharmaceutical preparations for treating diseases or disorders.
BICYCLIC DERIVATIVES
The present invention provides compounds of formula (I):
##STR00001##
which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.
BICYCLIC DERIVATIVES
The present invention provides compounds of formula (I):
##STR00001##
which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.
Inhibitors of heat shock factors and uses thereof
The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
Inhibitors of heat shock factors and uses thereof
The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.