Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

##STR00001##

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

##STR00001##

Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods relating thereto.

Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods relating thereto.

The present invention relates to a polycyclic compound and the use thereof. Specifically, the compound of the present invention has a structure as represented by formula (I), wherein the definitions of each group and each substituent are as described in the description. Also disclosed in the present invention are a method for preparing the compound and the use of the compound in regulating and treating related diseases caused by abnormal activity of YAP/TEAD.

##STR00001##

The present invention relates to a polycyclic compound and the use thereof. Specifically, the compound of the present invention has a structure as represented by formula (I), wherein the definitions of each group and each substituent are as described in the description. Also disclosed in the present invention are a method for preparing the compound and the use of the compound in regulating and treating related diseases caused by abnormal activity of YAP/TEAD.

##STR00001##

There are described ROR modulators of the formula (I), ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all substituents are defined herein.

There are described ROR modulators of the formula (I), ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all substituents are defined herein.