This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Disclosed is a compound containing a specific structure having an azomethine part, the compound being reversibly fluidized and non-fluidized by being irradiated with light.

Disclosed is a compound containing a specific structure having an azomethine part, the compound being reversibly fluidized and non-fluidized by being irradiated with light.

The present invention relates to novel 1-hexyl-1H-pyrazole-4,5-diamine derivative compounds of formula (I), to a composition for oxidation dyeing of the keratin fibres containing same, to a process for preparing the compounds of formula (I), to reaction intermediates, to an oxidation dyeing process using the composition, to the use of the compounds of formula (I) for oxidation dyeing of keratin fibres, and also to a kit; and to the 1-hexyl-4,5-diaminopyrazole derivative compounds of formula (I) below: ##STR00001##
and also the addition salts thereof with organic or mineral acids, the tautomers thereof, and the solvates thereof such as hydrates, in which ALK is as defined in the description.

The present invention relates to novel 1-hexyl-1H-pyrazole-4,5-diamine derivative compounds of formula (I), to a composition for oxidation dyeing of the keratin fibres containing same, to a process for preparing the compounds of formula (I), to reaction intermediates, to an oxidation dyeing process using the composition, to the use of the compounds of formula (I) for oxidation dyeing of keratin fibres, and also to a kit; and to the 1-hexyl-4,5-diaminopyrazole derivative compounds of formula (I) below: ##STR00001##
and also the addition salts thereof with organic or mineral acids, the tautomers thereof, and the solvates thereof such as hydrates, in which ALK is as defined in the description.

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

Disclosed herein are compounds of formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.