This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.

This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.

A chemical reaction is catalyzed in an organic solvent using a water soluble N-heterocyclic carbene homogeneous catalyst to form a reaction mixture. An aqueous phase in the reaction mixture. A solvent in which the catalyst is insoluble is added to the reaction mixture, causing the catalyst to migrate to the aqueous phase to form a catalyst-laden aqueous phase. The catalyst is extracted from the catalyst-laden aqueous phase.

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.

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The disclosure provides compositions and methods for inhibiting corrosion of a copper surface using a bis-imidazoline compound having an aromatic group, such as an aryl bis-imidazoline. The bis-imidazoline corrosion inhibitor can provide one or more advantage in use such as synergistic performance in aqueous and acidic media at low active dosages, resistance to decomposition or degradation in the presence of harsh reagents, ease of dispersion in an aqueous system, and improved thermal stability over conventional triazole based inhibitors. The disclosure also provides methods for the synthesis of bis-imidazoline compounds.

A method for producing -caprolactam involves a step of Beckmann-rearranging cyclohexanone oxime in a gas phase in the presence of a zeolite catalyst containing silicon and at least one element selected from alkaline earth metal elements and magnesium. The concentration of the above-described element in the zeolite catalyst is 3 ppm by mass or more and 10000 ppm by mass or less.

The present disclosure describes solid compositions comprising a paraffin inhibitor and a corrosion inhibitor. The paraffin inhibitors include polymers having various repeat units containing one or more ester moieties. The corrosion inhibitors can be imidazoline compounds, quaternary ammonium compounds, or a combination thereof. These solid compositions can be used to treat subterranean hydrocarbon-containing reservoir and can inhibit or reduce paraffin deposition in the reservoir and/or inhibit or reduce corrosion in a piece of equipment in contact with the reservoir.

The present disclosure describes solid compositions comprising a paraffin inhibitor and a corrosion inhibitor. The paraffin inhibitors include polymers having various repeat units containing one or more ester moieties. The corrosion inhibitors can be imidazoline compounds, quaternary ammonium compounds, or a combination thereof. These solid compositions can be used to treat subterranean hydrocarbon-containing reservoir and can inhibit or reduce paraffin deposition in the reservoir and/or inhibit or reduce corrosion in a piece of equipment in contact with the reservoir.

A method for producing -caprolactam involves a step of Beckmann-rearranging cyclohexanone oxime in a gas phase in the presence of a zeolite catalyst containing silicon and at least one element selected from alkaline earth metal elements and magnesium. The concentration of the above-described element in the zeolite catalyst is 3 ppm by mass or more and 10000 ppm by mass or less.

The present invention provides corrosion inhibiting compositions that incorporate at least one bis-imidazoline compound. In the practice of the present invention, a tetramine admixture enriched with respect to linear tetramine is used to prepare the bis-imidazoline compound. Enriched means at least 70 weight percent and up to 100% of the tetramine species included in the admixture includes a linear tetramine such as L-TETA.